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Helleberg L, Rubin A, Wolen RL, et al. A pharmacokinetic interaction in man between phenobarbitone and fenoprofen, a new anti-inflammatory agent. Br J Clin Pharmacol. 1974;1(5):371-4doi: 10.1111/j.1365-2125.1974.tb00271.x.
Helleberg, L., Rubin, A., Wolen, R. L., Rodda, B. E., Ridolfo, A. S., & Gruber, C. M. (1974). A pharmacokinetic interaction in man between phenobarbitone and fenoprofen, a new anti-inflammatory agent. British journal of clinical pharmacology, 1(5), 371-4. https://doi.org/10.1111/j.1365-2125.1974.tb00271.x
Helleberg, L, et al. "A pharmacokinetic interaction in man between phenobarbitone and fenoprofen, a new anti-inflammatory agent." British journal of clinical pharmacology vol. 1,5 (1974): 371-4. doi: https://doi.org/10.1111/j.1365-2125.1974.tb00271.x
Helleberg L, Rubin A, Wolen RL, Rodda BE, Ridolfo AS, Gruber CM. A pharmacokinetic interaction in man between phenobarbitone and fenoprofen, a new anti-inflammatory agent. Br J Clin Pharmacol. 1974 Oct;1(5):371-4. doi: 10.1111/j.1365-2125.1974.tb00271.x. PMID: 22454912; PMCID: PMC1402462.
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Br J Clin Pharmacol. 1974 Oct;1(5):371-4. doi: 10.1111/j.1365-2125.1974.tb00271.x.

A pharmacokinetic interaction in man between phenobarbitone and fenoprofen, a new anti-inflammatory agent.

British journal of clinical pharmacology

L Helleberg, A Rubin, R L Wolen, B E Rodda, A S Ridolfo, C M Gruber

Affiliations

  1. Lilly Laboratory for Clinical Research, 960 Locke Street, Indianapolis, Indiana, U.S.A.

PMID: 22454912 PMCID: PMC1402462 DOI: 10.1111/j.1365-2125.1974.tb00271.x

Abstract

1 The effect of repeated administration of phenobarbitone on the plasma disposition of fenoprofen (±-2-(3-phenoxyphenyl) propionic acid) was investigated in rats and man. 2 The plasma elimination rate constants increased significantly and the rats excreted proportionately more metabolized fenoprofen in the urine. These findings are consistent with an increase in the rate of metabolism of fenoprofen. 3 This interaction between phenobarbitone (and presumably other inducers of drug metabolizing enzymes) and fenoprofen should be considered when evaluating the clinical usefulness of fenoprofen.

References

  1. J Pharm Sci. 1972 May;61(5):739-45 - PubMed
  2. J Pharm Sci. 1971 Jul;60(7):1062-4 - PubMed
  3. J Pharm Sci. 1971 Dec;60(12):1797-801 - PubMed
  4. J Clin Invest. 1969 Dec;48(12):2202-9 - PubMed

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