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Kilborn JR, Turner P. Ro 3-4787, a new β-adrenoceptor blocking agent: Studies in normal volunteers. Br J Clin Pharmacol. 1974;1(2):143-9doi: 10.1111/j.1365-2125.1974.tb00223.x.
Kilborn, J. R., & Turner, P. (1974). Ro 3-4787, a new β-adrenoceptor blocking agent: Studies in normal volunteers. British journal of clinical pharmacology, 1(2), 143-9. https://doi.org/10.1111/j.1365-2125.1974.tb00223.x
Kilborn, J R, and Turner, P. "Ro 3-4787, a new β-adrenoceptor blocking agent: Studies in normal volunteers." British journal of clinical pharmacology vol. 1,2 (1974): 143-9. doi: https://doi.org/10.1111/j.1365-2125.1974.tb00223.x
Kilborn JR, Turner P. Ro 3-4787, a new β-adrenoceptor blocking agent: Studies in normal volunteers. Br J Clin Pharmacol. 1974 Apr;1(2):143-9. doi: 10.1111/j.1365-2125.1974.tb00223.x. PMID: 22454901; PMCID: PMC1402459.
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Br J Clin Pharmacol. 1974 Apr;1(2):143-9. doi: 10.1111/j.1365-2125.1974.tb00223.x.

Ro 3-4787, a new β-adrenoceptor blocking agent: Studies in normal volunteers.

British journal of clinical pharmacology

J R Kilborn, P Turner

Affiliations

  1. Department of Clinical Research, Roche Products Limted, Welwyn Garden City, Hertfordshire.

PMID: 22454901 PMCID: PMC1402459 DOI: 10.1111/j.1365-2125.1974.tb00223.x

Abstract

1 A new β-adrenoceptor blocking agent, Ro 3-4787, was administered orally to resting subjects. Peak levels of 106.2 ± 15.5 ng/ml were reached after 20 mg given in the fasting state. After intravenous administration, an inverse rectilinear relationship was shown between the log dose (2 mg-20 mg) and the heart rate during vigorous exercise on a bicycle ergometer. 2 A double-blind study in five normal subjects using 0.03 mg/kg and 0.15 mg/kg showed that propranolol and Ro 3-4787 were equally effective in reducing the exercise heart rate. There was an inverse correlation between the log plasma level before exercise and the heart rate during exercise for both drugs over the range studied.

References

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