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Watson JM, Richens A. The effects of salbutamol and terbutaline on physiological tremor, bronchial tone and heart rate. Br J Clin Pharmacol. 1974;1(3):223-7doi: 10.1111/j.1365-2125.1974.tb00240.x.
Watson, J. M., & Richens, A. (1974). The effects of salbutamol and terbutaline on physiological tremor, bronchial tone and heart rate. British journal of clinical pharmacology, 1(3), 223-7. https://doi.org/10.1111/j.1365-2125.1974.tb00240.x
Watson, J M, and Richens, A. "The effects of salbutamol and terbutaline on physiological tremor, bronchial tone and heart rate." British journal of clinical pharmacology vol. 1,3 (1974): 223-7. doi: https://doi.org/10.1111/j.1365-2125.1974.tb00240.x
Watson JM, Richens A. The effects of salbutamol and terbutaline on physiological tremor, bronchial tone and heart rate. Br J Clin Pharmacol. 1974 Jun;1(3):223-7. doi: 10.1111/j.1365-2125.1974.tb00240.x. PMID: 22454951; PMCID: PMC1402544.
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Br J Clin Pharmacol. 1974 Jun;1(3):223-7. doi: 10.1111/j.1365-2125.1974.tb00240.x.

The effects of salbutamol and terbutaline on physiological tremor, bronchial tone and heart rate.

British journal of clinical pharmacology

J M Watson, A Richens

Affiliations

  1. Department of Clinical Pharmacology, St Bartholomew's Hospital, London.

PMID: 22454951 PMCID: PMC1402544 DOI: 10.1111/j.1365-2125.1974.tb00240.x

Abstract

1 The effects of oral doses of the bronchodilator drugs, salbutamol (4 and 8 mg) and terbutaline (5 and 10 mg), on physiological tremor, bronchial tone, heart rate and blood pressure were studied in six normal subjects. 2 Both drugs produced a significant increase in physiological tremor, compared with placebo. Terbutaline, but not salbutamol, produced a dose related response. No significant differences were observed between drugs. 3 Terbutaline (5 and 10 mg) and salbutamol (8 mg) produced a significant bronchodilatation compared with placebo. Dose related responses were obtained with both drugs, although this reached significance only with terbutaline. 4 Both doses of each drug produced a tachycardia, although this was only statistically significant with the high doses. 5 No significant change in blood pressure was observed with either drug. 6 Peak effects of salbutamol occurred between 1 and 3 h and terbutaline between 1 and 4 hours. Both drugs were still active at 6 hours.

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