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Gilbert JC, Scott AK, Galloway DB, et al. Ethosuximide: liver enzyme induction and D-glucaric acid excretion. Br J Clin Pharmacol. 1974;1(3):249-52doi: 10.1111/j.1365-2125.1974.tb00245.x.
Gilbert, J. C., Scott, A. K., Galloway, D. B., & Petrie, J. C. (1974). Ethosuximide: liver enzyme induction and D-glucaric acid excretion. British journal of clinical pharmacology, 1(3), 249-52. https://doi.org/10.1111/j.1365-2125.1974.tb00245.x
Gilbert, J C, et al. "Ethosuximide: liver enzyme induction and D-glucaric acid excretion." British journal of clinical pharmacology vol. 1,3 (1974): 249-52. doi: https://doi.org/10.1111/j.1365-2125.1974.tb00245.x
Gilbert JC, Scott AK, Galloway DB, Petrie JC. Ethosuximide: liver enzyme induction and D-glucaric acid excretion. Br J Clin Pharmacol. 1974 Jun;1(3):249-52. doi: 10.1111/j.1365-2125.1974.tb00245.x. PMID: 22454956; PMCID: PMC1402543.
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Br J Clin Pharmacol. 1974 Jun;1(3):249-52. doi: 10.1111/j.1365-2125.1974.tb00245.x.

Ethosuximide: liver enzyme induction and D-glucaric acid excretion.

British journal of clinical pharmacology

J C Gilbert, A K Scott, D B Galloway, J C Petrie

Affiliations

  1. Department of Pharmacology, University Medical Buildings, Aberdeen.

PMID: 22454956 PMCID: PMC1402543 DOI: 10.1111/j.1365-2125.1974.tb00245.x

Abstract

1 A study has been carried out to determine if ethosuximide induces liver enzymes. 2 Ethosuximide did not affect the urinary excretion of D-glucaric acid by healthy adult subjects nor was the mean daily D-glucaric acid excretion of three epileptic children on long term ethosuximide therapy different from that of three matched controls. 3 Ethosuximide (10 mg/kg or 50 mg/kg daily) did not influence D-glucaric acid excretion or liver microsomal protein and cytochrome P450 contents of guinea pigs but at a dose of 100 mg/kg daily in rats it increased liver microsomal protein and cytochrome P450 without altering D-glucaric acid excretion. 4 These results suggest that at anticonvulsant doses ethosuximide is unlikely to induce liver enzymes. The precise relationship between D-glucaric acid excretion and liver enzyme induction remains in doubt.

References

  1. Lancet. 1971 Mar 20;1(7699):572-5 - PubMed
  2. Clin Chem. 1961 Dec;7:655-64 - PubMed
  3. Biochem Pharmacol. 1973 Mar 15;22(6):743-7 - PubMed
  4. Br J Pharmacol. 1973 Mar;47(3):615P - PubMed
  5. Biochem J. 1963 Jan;86(1):77-86 - PubMed
  6. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
  7. J Biol Chem. 1964 Jul;239:2370-8 - PubMed
  8. Lancet. 1971 Apr 24;1(7704):859 - PubMed

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