ACS Nano. 2012 Apr 24;6(4):3499-505. doi: 10.1021/nn300530b. Epub 2012 Mar 21.

Single-nanoparticle detection using a low-aspect-ratio pore.

ACS nano

Makusu Tsutsui, Sadato Hongo, Yuhui He, Masateru Taniguchi, Nobuhiro Gemma, Tomoji Kawai

PMID: 22424475 DOI: 10.1021/nn300530b

Abstract

We explored single-particle translocation through a low thickness-to-diameter aspect ratio Si(3)N(4) pore mimicking graphene nanopore structure by a resistive pulse method. Ionic conductance of 0.05 aspect ratio pores scales linearly with the diameter, indicating predominant contribution of the access resistance to the ion transport. We find that the access resistance changes little during particle translocation. Furthermore, we observe enhanced particle capture rates via the strong electric field extended outside the low-aspect-ratio pore mouth. We also demonstrate electrical discrimination of two different sized particles using the low-aspect-ratio pore sensor with the constant access resistance assumption. The present findings indicate the potential utility of nucleotide-sized graphene nanopores as an electrical sensing platform for single-base identification via transmembrane ionic current blockade detections.

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't