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Codullo V, McInnes IB. Synovial tissue response to treatment in psoriatic arthritis. Open Rheumatol J. 2011;5:133-7doi: 10.2174/1874312901105010133.
Codullo, V., & McInnes, I. B. (2011). Synovial tissue response to treatment in psoriatic arthritis. The open rheumatology journal, 5133-7. https://doi.org/10.2174/1874312901105010133
Codullo, Veronica, and McInnes, Iain B. "Synovial tissue response to treatment in psoriatic arthritis." The open rheumatology journal vol. 5 (2011): 133-7. doi: https://doi.org/10.2174/1874312901105010133
Codullo V, McInnes IB. Synovial tissue response to treatment in psoriatic arthritis. Open Rheumatol J. 2011;5:133-7. doi: 10.2174/1874312901105010133. Epub 2011 Dec 30. PMID: 22279513; PMCID: PMC3263446.
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Open Rheumatol J. 2011;5:133-7. doi: 10.2174/1874312901105010133. Epub 2011 Dec 30.

Synovial tissue response to treatment in psoriatic arthritis.

The open rheumatology journal

Veronica Codullo, Iain B McInnes

Affiliations

  1. University of Glasgow, UK.

PMID: 22279513 PMCID: PMC3263446 DOI: 10.2174/1874312901105010133

Abstract

Following its validation and wide application in rheumatoid arthritis (RA), synovial tissue analysis has recently been applied to studies on Psoriatic Arthritis (PsA). Such studies aim to thereby clarify its distinctive features and the nature of specific responses upon administration of disease modifying anti-rheumatic drug (DMARD) or biologic agents. In consequence, insights to disease pathogenesis, drugs' mechanisms of action (MOA) and biomarkers of response have emerged. Data from pilot and open-label studies, and recently from randomized controlled trials, have helped in refining the therapeutic approaches to PsA patients, by improving understanding of MOA and in provision of biomarkers of response. The availability of less invasive and reproducible analysis techniques to obtain and evaluate synovial biopsies will further enhance the utility of this approach in due course.

Keywords: Biologic therapy; biomarker; psoriatic arthritis; synovial tissue,

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