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Banji D, Banji OJ, Singh M, et al. Role of butea frondosa in ameliorating gastric markers in induced gastric lesions of rats. Indian J Pharm Sci. 2011;73(3):300-2doi: 10.4103/0250-474X.93522.
Banji, D., Banji, O. J., Singh, M., & Annamalai, A. R. (2011). Role of butea frondosa in ameliorating gastric markers in induced gastric lesions of rats. Indian journal of pharmaceutical sciences, 73(3), 300-2. https://doi.org/10.4103/0250-474X.93522
Banji, D, et al. "Role of butea frondosa in ameliorating gastric markers in induced gastric lesions of rats." Indian journal of pharmaceutical sciences vol. 73,3 (2011): 300-2. doi: https://doi.org/10.4103/0250-474X.93522
Banji D, Banji OJ, Singh M, Annamalai AR. Role of butea frondosa in ameliorating gastric markers in induced gastric lesions of rats. Indian J Pharm Sci. 2011 May;73(3):300-2. doi: 10.4103/0250-474X.93522. PMID: 22457555; PMCID: PMC3309651.
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Indian J Pharm Sci. 2011 May;73(3):300-2. doi: 10.4103/0250-474X.93522.

Role of butea frondosa in ameliorating gastric markers in induced gastric lesions of rats.

Indian journal of pharmaceutical sciences

D Banji, Otilia J F Banji, Meenu Singh, A R Annamalai

Affiliations

  1. Department of Pharmacology, Nalanda College of Pharmacy, Cherlapally-508 001, India.

PMID: 22457555 PMCID: PMC3309651 DOI: 10.4103/0250-474X.93522

Abstract

The study evaluated the ability of the alcohol extract of Butea frondosa to protect the gastro-duodenal lining from injury inflicted by acetic acid and pyloric ligation in rats. The induced gastric lesions lead to the generation of alkaline phosphatase and pepsin, which serve as important markers of gastric damage. Alcohol extract of Butea frondosa was administered in doses of 10, 100, 300 and 500 mg/kg as a single schedule and for the time dependent studies in a dose of 100 mg/kg for 7, 14, 21 and 28 days, respectively. Our studies reveal a decline in the formation of alkaline phosphatase and pepsin with 300 and 500 mg/kg of the extract and following treatment for 21 and 28 days, respectively. Extract of Butea frondosa produces significant diminution in the formation of gastric markers implying possible gastro-protective action.

Keywords: Alkaline phosphatase; Butea frondosa; markers; pepsin

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