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Motzo C, Porceddu ML, Maira G, et al. Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone. J Psychopharmacol. 1996;10(4):266-72doi: 10.1177/026988119601000402.
Motzo, C., Porceddu, M. L., Maira, G., Flore, G., Concas, A., Dazzi, L., & Biggio, G. (1996). Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone. Journal of psychopharmacology (Oxford, England), 10(4), 266-72. https://doi.org/10.1177/026988119601000402
Motzo, C, et al. "Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone." Journal of psychopharmacology (Oxford, England) vol. 10,4 (1996): 266-72. doi: https://doi.org/10.1177/026988119601000402
Motzo C, Porceddu ML, Maira G, Flore G, Concas A, Dazzi L, Biggio G. Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone. J Psychopharmacol. 1996 Jan;10(4):266-72. doi: 10.1177/026988119601000402. PMID: 22302972.
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J Psychopharmacol. 1996 Jan;10(4):266-72. doi: 10.1177/026988119601000402.

Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone.

Journal of psychopharmacology (Oxford, England)

C Motzo, M L Porceddu, G Maira, G Flore, A Concas, L Dazzi, G Biggio

Affiliations

  1. Department of Experimental Biology 'Bernardo Loddo,' University of Cagliari, Cagliari, Italy.

PMID: 22302972 DOI: 10.1177/026988119601000402

Abstract

The neurosteroid allopregnanolone is a potent and efficacious modulator of γ-aminobutyric acid (GABA) type A receptors. The effects of intracerebroventricular injection of allopregnanolone (5 to 15 μg in 5 μl) on basal and stress-induced changes in the extracellular concentrations of dopamine were investigated by microdialysis in various brain areas of freely moving rats and compared with those of the benzodiazepine midazolam (1 to 10 μg in 5 μl). Allopregnanolone reduced (by a maximum of 65 to 75%) basal dopamine content in the prefrontal cortex and nucleus accumbens in a dose-dependent manner, but had no effect on dopamine output in the striatum. Allopregnanolone (10 to 15 μg) also completely prevented the increase in extracellular dopamine concentrations in the nucleus accumbens and cerebral cortex induced by foot-shock stress. Midazolam reduced basal dopamine content in all three brain regions studied as well as the stress- induced increase in dopamine content in the nucleus accumbens and cerebral cortex with a greater potency than allopregnanolone. These results suggest that endogenous neurosteroids may participate in the GABAergic modulation of dopaminergic transmission in the rat cerebral cortex and nucleus accumbens, two brain areas which are important in the regulation of emotional processes. These agents do not appear to affect striatal dopaminergic transmission which modulates motor function.

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