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Tehraninejad ESh, Nekoo EA, Ezabadi Z, et al. Half-dose, long-acting gonadotropin-releasing hormone agonist (Diphereline) is comparable with daily injections of short-acting gonadotropin-releasing hormone agonist (Suprefact) in IVF/ICSI cycles. Arch Med Sci. 2010;6(6):945-9doi: 10.5114/aoms.2010.19306.
Tehraninejad, E. S. h., Nekoo, E. A., Ezabadi, Z., Rashidi, B. H., Amirchaghmaghi, E., & Matroud, E. P. (2010). Half-dose, long-acting gonadotropin-releasing hormone agonist (Diphereline) is comparable with daily injections of short-acting gonadotropin-releasing hormone agonist (Suprefact) in IVF/ICSI cycles. Archives of medical science : AMS, 6(6), 945-9. https://doi.org/10.5114/aoms.2010.19306
Tehraninejad, Ensieh Sh, et al. "Half-dose, long-acting gonadotropin-releasing hormone agonist (Diphereline) is comparable with daily injections of short-acting gonadotropin-releasing hormone agonist (Suprefact) in IVF/ICSI cycles." Archives of medical science : AMS vol. 6,6 (2010): 945-9. doi: https://doi.org/10.5114/aoms.2010.19306
Tehraninejad ESh, Nekoo EA, Ezabadi Z, Rashidi BH, Amirchaghmaghi E, Matroud EP. Half-dose, long-acting gonadotropin-releasing hormone agonist (Diphereline) is comparable with daily injections of short-acting gonadotropin-releasing hormone agonist (Suprefact) in IVF/ICSI cycles. Arch Med Sci. 2010 Dec;6(6):945-9. doi: 10.5114/aoms.2010.19306. Epub 2010 Dec 29. PMID: 22427771; PMCID: PMC3302709.
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Arch Med Sci. 2010 Dec;6(6):945-9. doi: 10.5114/aoms.2010.19306. Epub 2010 Dec 29.

Half-dose, long-acting gonadotropin-releasing hormone agonist (Diphereline) is comparable with daily injections of short-acting gonadotropin-releasing hormone agonist (Suprefact) in IVF/ICSI cycles.

Archives of medical science : AMS

Ensieh Sh Tehraninejad, Elham Azimi Nekoo, Zahra Ezabadi, Batool H Rashidi, Elham Amirchaghmaghi, Elham Pour Matroud

Affiliations

  1. Endocrinology and Female Infertility Department, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

PMID: 22427771 PMCID: PMC3302709 DOI: 10.5114/aoms.2010.19306

Abstract

INTRODUCTION: The aim of the study was to compare the efficacy of half-dose, long-acting GnRH analogue (Diphereline) with Suprefact in IVF/ICSI (in vitro fertilization/intracytoplasmic sperm injection) cycles.

MATERIAL AND METHODS: In this randomized clinical trial performed in Royan Institute, 126 infertile women who were first time candidates for IVF/ICSI were enrolled. Patients were randomly divided into two groups by using a random number table. In one group, 62 patients received a single half dose, 1.87 mg Diphereline, in mid-luteal phase. In the other group, 64 cases were treated with buserelin from the previous mid-luteal phase. P value less than 0.05 was considered significant.

RESULTS: The mean age of patients in the Diphereline and Suprefact groups was 27.9 ±3.6 and 29.6 ±3.5 years, respectively (p = 0.01). In the Diphereline group, the mean number of used gonadotropins was 25.6 ±12.1 ampoules, while in the second group it was 25.9 ±8.5 ampoules. Numbers of retrieved and MII oocytes were significantly higher in the Diphereline group (12.1 ±6.3 and 9.6 ±5.5) in comparison to the Suprefact group (9.4 ±6.4 and 7.2 ±5.1). Although the number of developed embryos in the Diphereline group was statistically higher than in the Suprefact group (6.1 ±3.9 vs. 4.7 ±3.4, p = 0.04) there was no significant difference in pregnancy rate (37.1%, 95% CI [26.16-49.54] vs. 37.5%, 95% CI [26.67-49.75]).

CONCLUSIONS: A half-dose, long-acting GnRH agonist can be successfully used in ovarian stimulation and produces a higher number of MII oocytes and embryos. The pregnancy rates with this method are acceptable.

Keywords: GnRH agonist; assisted reproductive technology; diphereline; half dose

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