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Mullen MP, Berry DP, Howard DJ, et al. Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 (IGF-1) Gene are Associated with Performance in Holstein-Friesian Dairy Cattle. Front Genet. 2011;2:3doi: 10.3389/fgene.2011.00003.
Mullen, M. P., Berry, D. P., Howard, D. J., Diskin, M. G., Lynch, C. O., Giblin, L., Kenny, D. A., Magee, D. A., Meade, K. G., & Waters, S. M. (2011). Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 (IGF-1) Gene are Associated with Performance in Holstein-Friesian Dairy Cattle. Frontiers in genetics, 23. https://doi.org/10.3389/fgene.2011.00003
Mullen, Michael Paul, et al. "Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 (IGF-1) Gene are Associated with Performance in Holstein-Friesian Dairy Cattle." Frontiers in genetics vol. 2 (2011): 3. doi: https://doi.org/10.3389/fgene.2011.00003
Mullen MP, Berry DP, Howard DJ, Diskin MG, Lynch CO, Giblin L, Kenny DA, Magee DA, Meade KG, Waters SM. Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 (IGF-1) Gene are Associated with Performance in Holstein-Friesian Dairy Cattle. Front Genet. 2011 Feb 16;2:3. doi: 10.3389/fgene.2011.00003. eCollection 2011. PMID: 22303302; PMCID: PMC3268377.
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Front Genet. 2011 Feb 16;2:3. doi: 10.3389/fgene.2011.00003. eCollection 2011.

Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 (IGF-1) Gene are Associated with Performance in Holstein-Friesian Dairy Cattle.

Frontiers in genetics

Michael Paul Mullen, Donagh P Berry, Dawn J Howard, Michael G Diskin, Ciaran O Lynch, Linda Giblin, David A Kenny, David A Magee, Kieran G Meade, Sinead M Waters

Affiliations

  1. Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre Teagasc, Athenry, County Galway, Ireland.

PMID: 22303302 PMCID: PMC3268377 DOI: 10.3389/fgene.2011.00003

Abstract

Insulin-like growth factor 1 (IGF-1) has been shown to be associated with fertility, growth, and development in cattle. The aim of this study was to (1) identify novel single nucleotide polymorphisms (SNPs) in the bovine IGF-1 gene and alongside previously identified SNPs (2) determine their association with traits of economic importance in Holstein-Friesian dairy cattle. Nine novel SNPs were identified across a panel of 22 beef and dairy cattle by sequence analysis of the 5' promoter, intronic, and 3' regulatory regions, encompassing ~5 kb of IGF-1. Genotyping and associations with daughter performance for milk production, fertility, survival, and measures of body size were undertaken on 848 Holstein-Friesian AI sires. Using multiple regression analysis nominal associations (P < 0.05) were identified between six SNPs (four novel and two previously identified) and milk composition, survival, body condition score, and body size. The C allele of AF017143 a previously published SNP (C-512T) in the promoter region of IGF-1 predicted to introduce binding sites for transcription factors HSF1 and ZNF217 was associated (P < 0.05) with increased cow carcass weight (i.e., an indicator of mature cow size). Novel SNPs were identified in the 3' region of IGF-1 were associated (P < 0.05) with functional survival and chest width. The remaining four SNPs, all located within introns of IGF-1 were associated (P < 0.05) with milk protein yield, milk fat yield, milk fat concentration, somatic cell score, carcass conformation, and carcass fat. Results of this study further demonstrate the multifaceted influences of IGF-1 on milk production and growth related traits in cattle.

Keywords: Holstein-Friesian dairy cattle; performance; single nucleotide polymorphism

References

  1. J Anim Sci. 1988 Dec;66(12):3059-67 - PubMed
  2. Bioinformatics. 2007 Nov 1;23(21):2947-8 - PubMed
  3. J Anim Sci. 2009 Jan;87(1):46-56 - PubMed
  4. Anim Genet. 2009 Oct;40(5):766-9 - PubMed
  5. Biometrics. 1980 Dec;36(4):627-42 - PubMed
  6. Nucleic Acids Res. 1995 Dec 11;23(23):4878-84 - PubMed
  7. Domest Anim Endocrinol. 2003 Nov;25(4):315-28 - PubMed
  8. Anim Genet. 2005 Feb;36(1):58-62 - PubMed
  9. Mol Pathol. 2001 Oct;54(5):311-6 - PubMed
  10. J Endocrinol. 1999 Sep;162(3):457-65 - PubMed
  11. Theriogenology. 2006 Apr 1;65(6):1180-90 - PubMed
  12. J Dairy Sci. 2006 Apr;89(4):1222-34 - PubMed
  13. Methods Mol Biol. 2000;132:365-86 - PubMed
  14. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W696-700 - PubMed
  15. Endocrinology. 1981 Apr;108(4):1265-71 - PubMed
  16. J Anim Sci. 1995 Jul;73(7):1927-32 - PubMed
  17. J Anim Sci. 2009 Mar;87(3):835-43 - PubMed
  18. Epigenetics. 2009 Feb 16;4(2):100-6 - PubMed
  19. Endocrinology. 1983 Jul;113(1):297-305 - PubMed
  20. Endocr Rev. 1994 Feb;15(1):80-101 - PubMed
  21. Reprod Domest Anim. 2008 Jul;43 Suppl 2:31-9 - PubMed
  22. Neuro Endocrinol Lett. 2008 Dec;29(6):981-9 - PubMed
  23. J Dairy Res. 1998 Feb;65(1):93-100 - PubMed
  24. Anim Reprod Sci. 2006 Dec;96(3-4):297-311 - PubMed
  25. J Biol Chem. 2002 Apr 5;277(14):11802-10 - PubMed
  26. Theor Appl Genet. 1968 Jun;38(6):226-31 - PubMed
  27. J Dairy Sci. 1998 Oct;81(10):2723-8 - PubMed
  28. J Dairy Sci. 2010 Dec;93(12):5959-69 - PubMed
  29. J Anim Sci. 2001 Jul;79(7):1757-62 - PubMed
  30. J Anim Sci. 2004;82 E-Suppl:E239-244 - PubMed
  31. Anim Genet. 2011 Feb;42(1):39-49 - PubMed
  32. J Dairy Sci. 2007 Feb;90(2):649-58 - PubMed
  33. J Anim Sci. 1997 Feb;75(2):317-24 - PubMed
  34. Domest Anim Endocrinol. 2010 May;38(4):211-21 - PubMed
  35. Anim Genet. 2010 Dec;41(6):579-88 - PubMed
  36. Domest Anim Endocrinol. 1999 Oct;17(2-3):209-18 - PubMed
  37. Endocr Rev. 1989 Feb;10(1):68-91 - PubMed
  38. J Anim Sci. 2004 Feb;82(2):459-71 - PubMed
  39. J Genet Genomics. 2008 Mar;35(3):163-9 - PubMed
  40. Nature. 2008 Nov 6;456(7218):18-21 - PubMed
  41. Theriogenology. 2005 Dec;64(9):1977-94 - PubMed
  42. Anim Genet. 1997 Feb;28(1):21-7 - PubMed
  43. Nature. 2009 Oct 8;461(7265):747-53 - PubMed
  44. J Dairy Sci. 2007 Mar;90(3):1310-25 - PubMed
  45. Nat Genet. 2006 Jul;38(7):813-8 - PubMed
  46. J Anim Sci. 2000 Sep;78(9):2305-13 - PubMed
  47. Vitam Horm. 1994;48:1-58 - PubMed
  48. Anim Genet. 1997 Apr;28(2):155-6 - PubMed
  49. Domest Anim Endocrinol. 2005 Apr;28(3):296-307 - PubMed

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