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Spindler J, Hackett J, Qiu X, et al. Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection. Adv Virol. 2011;2011:268214doi: 10.1155/2011/268214.
Spindler, J., Hackett, J., Qiu, X., Wiegand, A., Boltz, V. F., Swanson, P., Bream, J. H., Jacobson, L. P., Li, X., Rinaldo, C. R., Wolinsky, S. M., Coffin, J. M., Kearney, M. F., & Mellors, J. W. (2011). Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection. Advances in virology, 2011268214. https://doi.org/10.1155/2011/268214
Spindler, J, et al. "Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection." Advances in virology vol. 2011 (2011): 268214. doi: https://doi.org/10.1155/2011/268214
Spindler J, Hackett J, Qiu X, Wiegand A, Boltz VF, Swanson P, Bream JH, Jacobson LP, Li X, Rinaldo CR, Wolinsky SM, Coffin JM, Kearney MF, Mellors JW. Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection. Adv Virol. 2011;2011:268214. doi: 10.1155/2011/268214. Epub 2011 Nov 21. PMID: 22282703; PMCID: PMC3265298.
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Adv Virol. 2011;2011:268214. doi: 10.1155/2011/268214. Epub 2011 Nov 21.

Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection.

Advances in virology

J Spindler, J Hackett, X Qiu, A Wiegand, V F Boltz, P Swanson, J H Bream, L P Jacobson, X Li, C R Rinaldo, S M Wolinsky, J M Coffin, M F Kearney, J W Mellors

Affiliations

  1. HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702-1201, USA.

PMID: 22282703 PMCID: PMC3265298 DOI: 10.1155/2011/268214

Abstract

Xenotropic MLV-Related Virus (XMRV) was recently reported to be associated with prostate cancer and chronic fatigue syndrome (CFS). Infection was also reported in 3.7% of healthy individuals. These highly reported frequencies of infection prompted concerns about the possibility of a new, widespread retroviral epidemic. The Multicenter AIDS Cohort Study (MACS) provides an opportunity to assess the prevalence of XMRV infection and its association with HIV-1 infection among men who have sex with men. Reliable detection of XMRV infection requires the application of multiple diagnostic methods, including detection of human antibodies to XMRV and detection of XMRV nucleic acid. We, therefore, tested 332 patient plasma and PBMC samples obtained from recent visits in a subset of patients in the MACS cohort for XMRV antibodies using Abbott prototype ARCHITECT chemiluminescent immunoassays (CMIAs) and for XMRV RNA and proviral DNA using a XMRV single-copy qPCR assay (X-SCA). Although 9 of 332 (2.7%) samples showed low positive reactivity against a single antigen in the CMIA, none of these samples or matched controls were positive for plasma XMRV RNA or PBMC XMRV DNA by X-SCA. Thus, we found no evidence of XMRV infection among men in the MACS regardless of HIV-1 serostatus.

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