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Yi J, Park JS, Hong KH, et al. Serum capacity to neutralize superantigens does not affect the outcome of Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis. 2012;doi: 10.1007/s10096-011-1541-2.
Yi, J., Park, J. S., Hong, K. H., Lee, S. H., & Kim, E. C. (2012). Serum capacity to neutralize superantigens does not affect the outcome of Staphylococcus aureus bacteremia. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, . https://doi.org/10.1007/s10096-011-1541-2
Yi, J, et al. "Serum capacity to neutralize superantigens does not affect the outcome of Staphylococcus aureus bacteremia." European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology vol. (2012). doi: https://doi.org/10.1007/s10096-011-1541-2
Yi J, Park JS, Hong KH, Lee SH, Kim EC. Serum capacity to neutralize superantigens does not affect the outcome of Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis. 2012 Jan 31; doi: 10.1007/s10096-011-1541-2. Epub 2012 Jan 31. PMID: 22290348.
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Eur J Clin Microbiol Infect Dis. 2012 Jan 31; doi: 10.1007/s10096-011-1541-2. Epub 2012 Jan 31.

Serum capacity to neutralize superantigens does not affect the outcome of Staphylococcus aureus bacteremia.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

J Yi, J S Park, K-H Hong, S-H Lee, E-C Kim

Affiliations

  1. Department of Laboratory Medicine, Pusan National University School of Medicine, Yangsan, Korea.

PMID: 22290348 DOI: 10.1007/s10096-011-1541-2

Abstract

Staphylococcal superantigens (SAg) could play an important role in sepsis by activating numerous T cells. We investigated whether serum capacity to neutralize SAgs can be a prognostic factor in Staphylococcus aureus bacteremia (SAB). In a university hospital, 105 consecutive SAB patients were enrolled during a 12-month period. The earliest serum samples prior to SAB onset were stored for a later T cell proliferation assay. Multiplex polymerase chain reaction (PCR) for 19 SAg genes was performed for S. aureus blood isolates. To determine the serum capacity to neutralize SAgs, T cell proliferation by the culture supernatant of each S. aureus isolate was measured in the presence and absence of the corresponding patient's serum. Twenty-six (24.8%) patients died within 4 weeks from SAB onset. Vascular catheter-related infection was associated with survival for ≥4 weeks. Unknown primary focus, Simplified Acute Physiology Score-II (SAPS-II), and specific SAg genes (tst, sec, sel, or sep) were associated with the 4-week mortality. No variables related to T cell proliferation assay showed statistical significance. In the multivariate analysis, SAPS-II ≥33 and tst were independently associated with the 4-week mortality. Serum capacity to neutralize SAg does not significantly affect SAB outcome. SAPS-II ≥33 and tst are independent predictors of the 4-week mortality.

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