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Hamdy NM, El-Wakeel L, Suwailem SM. Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker, Non-Obese Congestive Heart Failure, Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production. Indian J Clin Biochem. 2011;26(2):140-5doi: 10.1007/s12291-010-0106-y.
Hamdy, N. M., El-Wakeel, L., & Suwailem, S. M. (2011). Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker, Non-Obese Congestive Heart Failure, Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production. Indian journal of clinical biochemistry : IJCB, 26(2), 140-5. https://doi.org/10.1007/s12291-010-0106-y
Hamdy, Nadia M, et al. "Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker, Non-Obese Congestive Heart Failure, Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production." Indian journal of clinical biochemistry : IJCB vol. 26,2 (2011): 140-5. doi: https://doi.org/10.1007/s12291-010-0106-y
Hamdy NM, El-Wakeel L, Suwailem SM. Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker, Non-Obese Congestive Heart Failure, Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production. Indian J Clin Biochem. 2011 Apr;26(2):140-5. doi: 10.1007/s12291-010-0106-y. Epub 2011 Jan 13. PMID: 22468040; PMCID: PMC3107402.
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Indian J Clin Biochem. 2011 Apr;26(2):140-5. doi: 10.1007/s12291-010-0106-y. Epub 2011 Jan 13.

Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker, Non-Obese Congestive Heart Failure, Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production.

Indian journal of clinical biochemistry : IJCB

Nadia M Hamdy, Lamiaa El-Wakeel, Salwa M Suwailem

PMID: 22468040 PMCID: PMC3107402 DOI: 10.1007/s12291-010-0106-y

Abstract

The EGF-R, also known as HER-1 or erbB-1 (EGF-R/HER-1/erbB-1), is a member of the human epithelial receptor tyrosine kinase family. sEGF-R is considered to play a role in cardiac (patho)physiology. We aimed to investigate whether soluble EGF-R is increased in congestive heart failure (CHF) patients and if related to disease severity. Soluble EGF-R, vitamin D, parathyroid hormone (PTH) was studied, and being evaluated in relation to Ca(2+), lipids, hsCRP, fibrinogen, serotonin, norepinepherine (NE). The study compared non-smoker, non-obese male CHF patients (n = 50) with age and gender-matched essential hypertension (HTN) patients (n = 20). Moreover, comparison with healthy control volunteers (n = 20) were employed. EGF-R/HER-1/erbB-1 was higher (P = 0.013) in 50 CHF male patients mean 12 ± 0.7 fmol/ml, than in 20 HTN, 9.25 ± 0.6 fmol/ml or in 20 controls, 6.25 ± 1 fmol/ml. Serum EGF-R levels correlated positively with hsCRP and NE, and were highest among CVD patients (n = 70) as well as negatively with vitamin D and HDL-C. EGF-R/HER-1/erbB-1 levels are increased in HTN and more in CHF patients. This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Moreover, contributing to the complex process of the inflammatory component of atherosclerosis in hypertensive patients that leads eventually to CHF.

Keywords: 25-hydroxy vitamin D; CHF; Catecholamines; Depression; EGF-R/HER-1/erbB-1; Fibrinogen

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