Display options
Cite
Zarrindast MR, Roushan-Zamir F, Amir-Rahmat F, et al. Potentiation of licking in rats by stimulation of both D-1 and D-2 dopamine receptors. J Psychopharmacol. 1992;6(3):395-8doi: 10.1177/026988119200600309.
Zarrindast, M. R., Roushan-Zamir, F., Amir-Rahmat, F., & Moslehi, M. (1992). Potentiation of licking in rats by stimulation of both D-1 and D-2 dopamine receptors. Journal of psychopharmacology (Oxford, England), 6(3), 395-8. https://doi.org/10.1177/026988119200600309
Zarrindast, M R, et al. "Potentiation of licking in rats by stimulation of both D-1 and D-2 dopamine receptors." Journal of psychopharmacology (Oxford, England) vol. 6,3 (1992): 395-8. doi: https://doi.org/10.1177/026988119200600309
Zarrindast MR, Roushan-Zamir F, Amir-Rahmat F, Moslehi M. Potentiation of licking in rats by stimulation of both D-1 and D-2 dopamine receptors. J Psychopharmacol. 1992 Jan;6(3):395-8. doi: 10.1177/026988119200600309. PMID: 22291386.
Copy Download .nbib Format: NLM
Share it on

J Psychopharmacol. 1992 Jan;6(3):395-8. doi: 10.1177/026988119200600309.

Potentiation of licking in rats by stimulation of both D-1 and D-2 dopamine receptors.

Journal of psychopharmacology (Oxford, England)

M R Zarrindast, F Roushan-Zamir, F Amir-Rahmat, M Moslehi

Affiliations

  1. Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran.

PMID: 22291386 DOI: 10.1177/026988119200600309

Abstract

Apomorphine-induced licking in rats was assessed by recording the total number of licks by direct observation. Apomorphine induced licking dose dependently. The maximum response was obtained by 0.5 mg/kg of the drug and 30 min after drug administration. Pre-treatment with dopamine antagonists, sulpiride and SCH 23390 decreased the apomorphine effect. Pre-treatment of animals with reserpine+α-methyl-p-tyrosine (AMPT) increased apomorphine-induced licking. In normal rats the D-2 agonist quinpirole and the D-1 agonist SKF 38393 also induced significant licking. The effect of quinpirole or SKF 38393 was decreased by reserpine+AMPT pre-treatment. Combined treatment with SKF 38393 and quinpirole induced more intense licking in both reserpinized and non-reserpinized animals. It is therefore concluded that the apomorphine-induced licking is mediated through both D-1 and D-2 receptors, and that pre-treatment with reserpine hypersensitizes these receptors to the drug effect. However, for either SKF 38393- or quinpirole-induced licking, the presence of endogenous dopamine seems essential.

Publication Types