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Flirski M, Sobow T, Kloszewska I. Behavioural genetics of Alzheimer's disease: a comprehensive review. Arch Med Sci. 2011;7(2):195-210doi: 10.5114/aoms.2011.22068.
Flirski, M., Sobow, T., & Kloszewska, I. (2011). Behavioural genetics of Alzheimer's disease: a comprehensive review. Archives of medical science : AMS, 7(2), 195-210. https://doi.org/10.5114/aoms.2011.22068
Flirski, Marcin, et al. "Behavioural genetics of Alzheimer's disease: a comprehensive review." Archives of medical science : AMS vol. 7,2 (2011): 195-210. doi: https://doi.org/10.5114/aoms.2011.22068
Flirski M, Sobow T, Kloszewska I. Behavioural genetics of Alzheimer's disease: a comprehensive review. Arch Med Sci. 2011 Apr;7(2):195-210. doi: 10.5114/aoms.2011.22068. Epub 2011 May 17. PMID: 22291757; PMCID: PMC3258720.
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Arch Med Sci. 2011 Apr;7(2):195-210. doi: 10.5114/aoms.2011.22068. Epub 2011 May 17.

Behavioural genetics of Alzheimer's disease: a comprehensive review.

Archives of medical science : AMS

Marcin Flirski, Tomasz Sobow, Iwona Kloszewska

Affiliations

  1. Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Poland.

PMID: 22291757 PMCID: PMC3258720 DOI: 10.5114/aoms.2011.22068

Abstract

Behavioural and psychological symptoms of dementia (BPSD) are present in the course of the illness in up to 90% of patients with Alzheimer's disease (AD). They are the main source of caregiver burden and one of the major factors contributing to early institutionalization. The involvement of a genetic component in BPSD aetiology seems beyond controversy, though the exact significance of particular polymorphisms is uncertain in the majority of cases. Multiple genes have been assessed for their putative influence on BPSD risk. In this paper we review the behavioural genetics of AD, particularly the importance, with respect to BPSD risk, of genes coding for apolipoprotein E and proteins involved in the process of neurotransmission: serotonin receptors, serotonin transporter, COMT, MAO-A, tryptophan hydroxylase and dopamine receptors. A general conclusion is the striking inconsistency of the findings, unsurprising in the field of psychiatric genetics. The potential reasons for such discrepancy are exhaustively discussed.

Keywords: Alzheimer’s disease; behavioural and psychological symptoms of dementia; behavioural disturbances; genetics; polymorphisms

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