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Maccauro G, Spinelli MS, Mauro S, et al. Physiopathology of spine metastasis. Int J Surg Oncol. 2011;2011:107969doi: 10.1155/2011/107969.
Maccauro, G., Spinelli, M. S., Mauro, S., Perisano, C., Graci, C., & Rosa, M. A. (2011). Physiopathology of spine metastasis. International journal of surgical oncology, 2011107969. https://doi.org/10.1155/2011/107969
Maccauro, Giulio, et al. "Physiopathology of spine metastasis." International journal of surgical oncology vol. 2011 (2011): 107969. doi: https://doi.org/10.1155/2011/107969
Maccauro G, Spinelli MS, Mauro S, Perisano C, Graci C, Rosa MA. Physiopathology of spine metastasis. Int J Surg Oncol. 2011;2011:107969. doi: 10.1155/2011/107969. Epub 2011 Aug 10. PMID: 22312491; PMCID: PMC3265280.
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Int J Surg Oncol. 2011;2011:107969. doi: 10.1155/2011/107969. Epub 2011 Aug 10.

Physiopathology of spine metastasis.

International journal of surgical oncology

Giulio Maccauro, Maria Silvia Spinelli, Sigismondo Mauro, Carlo Perisano, Calogero Graci, Michele Attilio Rosa

Affiliations

  1. Department of Orthopaedics and Traumatology, Agostino Gemelli Hospital, Catholic University, L.go F. Vito, 1-00168 Rome, Italy.

PMID: 22312491 PMCID: PMC3265280 DOI: 10.1155/2011/107969

Abstract

The metastasis is the spread of cancer from one part of the body to another. Two-thirds of patients with cancer will develop bone metastasis. Breast, prostate and lung cancer are responsible for more than 80% of cases of metastatic bone disease. The spine is the most common site of bone metastasis. A spinal metastasis may cause pain, instability and neurological injuries. The diffusion through Batson venous system is the principal process of spinal metastasis, but the dissemination is possible also through arterial and lymphatic system or by contiguity. Once cancer cells have invaded the bone, they produce growth factors that stimulate osteoblastic or osteolytic activity resulting in bone remodeling with release of other growth factors that lead to a vicious cycle of bone destruction and growth of local tumour.

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