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Gucalp A, Traina TA. Triple-negative breast cancer: adjuvant therapeutic options. Chemother Res Pract. 2011;2011:696208doi: 10.1155/2011/696208.
Gucalp, A., & Traina, T. A. (2011). Triple-negative breast cancer: adjuvant therapeutic options. Chemotherapy research and practice, 2011696208. https://doi.org/10.1155/2011/696208
Gucalp, Ayca, and Traina, Tiffany A. "Triple-negative breast cancer: adjuvant therapeutic options." Chemotherapy research and practice vol. 2011 (2011): 696208. doi: https://doi.org/10.1155/2011/696208
Gucalp A, Traina TA. Triple-negative breast cancer: adjuvant therapeutic options. Chemother Res Pract. 2011;2011:696208. doi: 10.1155/2011/696208. Epub 2011 Jun 21. PMID: 22312556; PMCID: PMC3265248.
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Chemother Res Pract. 2011;2011:696208. doi: 10.1155/2011/696208. Epub 2011 Jun 21.

Triple-negative breast cancer: adjuvant therapeutic options.

Chemotherapy research and practice

Ayca Gucalp, Tiffany A Traina

Affiliations

  1. Breast Cancer Medicine Service, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

PMID: 22312556 PMCID: PMC3265248 DOI: 10.1155/2011/696208

Abstract

Triple-negative breast cancer (TNBC), a subtype distinguished by negative immunohistochemical assays for expression of the estrogen and progesterone receptors (ER/PR) and human epidermal growth factor receptor-2(HER2) represents 15% of all breast cancers. Patients with TNBC generally experience a more aggressive clinical course with increased risk of disease progression and poorer overall survival. Furthermore, this subtype accounts for a disproportionate number of disease-related mortality in part due to its aggressive natural history and our lack of effective targeted agents beyond conventional cytotoxic chemotherapy. In this paper, we will review the epidemiology, risk factors, prognosis, and the molecular and clinicopathologic features that distinguish TNBC from other subtypes of breast cancer. In addition, we will examine the available data for the use of cytotoxic chemotherapy in the treatment of TNBC in both the neoadjuvant and adjuvant setting and explore the ongoing development of newer targeted agents.

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