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de Almeida JC, Alves CL, de Abreu LC, et al. Involvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise. Int Arch Med. 2012;5(1):4doi: 10.1186/1755-7682-5-4.
de Almeida, J. C., Alves, C. L., de Abreu, L. C., Sato, M. A., Fonseca, F. L., de Mello Monteiro, C. B., Vanderlei, L. C., Macedo, H., Tavares, C. M., Herrero, D., Rodrigues, L. M., & Valenti, V. E. (2012). Involvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise. International archives of medicine, 5(1), 4. https://doi.org/10.1186/1755-7682-5-4
de Almeida, Júlio C, et al. "Involvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise." International archives of medicine vol. 5,1 (2012): 4. doi: https://doi.org/10.1186/1755-7682-5-4
de Almeida JC, Alves CL, de Abreu LC, Sato MA, Fonseca FL, de Mello Monteiro CB, Vanderlei LC, Macedo H, Tavares CM, Herrero D, Rodrigues LM, Valenti VE. Involvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise. Int Arch Med. 2012 Feb 07;5(1):4. doi: 10.1186/1755-7682-5-4. PMID: 22313592; PMCID: PMC3395876.
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Int Arch Med. 2012 Feb 07;5(1):4. doi: 10.1186/1755-7682-5-4.

Involvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise.

International archives of medicine

Júlio C de Almeida, Clodoaldo L Alves, Luiz Carlos de Abreu, Monica A Sato, Fernando L Fonseca, Carlos B de Mello Monteiro, Luiz Carlos M Vanderlei, Hugo Macedo, Carlos M Tavares, Dafne Herrero, Luciano Mr Rodrigues, Vitor E Valenti

Affiliations

  1. Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Av, Príncipe de Gales, 821, 09060-650, Santo André, SP, Brazil. [email protected].

PMID: 22313592 PMCID: PMC3395876 DOI: 10.1186/1755-7682-5-4

Abstract

In this minireview we describe the involvement of the atrial natriuretic peptide (ANP) in cardiovascular pathophysiology and exercise. The ANP has a broad homeostatic role and exerts complex effects on the cardio-circulatory hemodynamics, it is produced by the left atrium and has a key role in regulating sodium and water balance in mammals and humans. The dominant stimulus for its release is atrial wall tension, commonly caused by exercise. The ANP is involved in the process of lipolysis through a cGMP signaling pathway and, as a consequence, reducing blood pressure by decreasing the sensitivity of vascular smooth muscle to the action of vasoconstrictors and regulate fluid balance. The increase of this hormone is associated with better survival in patients with chronic heart failure (CHF). This minireview provides new evidence based on recent studies related to the beneficial effects of exercise in patients with cardiovascular disease, focusing on the ANP.

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