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Shifren A, Witt C, Christie C, et al. Mechanisms of remodeling in asthmatic airways. J Allergy (Cairo). 2012;2012:316049doi: 10.1155/2012/316049.
Shifren, A., Witt, C., Christie, C., & Castro, M. (2012). Mechanisms of remodeling in asthmatic airways. Journal of allergy, 2012316049. https://doi.org/10.1155/2012/316049
Shifren, Adrian, et al. "Mechanisms of remodeling in asthmatic airways." Journal of allergy vol. 2012 (2012): 316049. doi: https://doi.org/10.1155/2012/316049
Shifren A, Witt C, Christie C, Castro M. Mechanisms of remodeling in asthmatic airways. J Allergy (Cairo). 2012;2012:316049. doi: 10.1155/2012/316049. Epub 2012 Jan 19. PMID: 22315625; PMCID: PMC3270414.
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J Allergy (Cairo). 2012;2012:316049. doi: 10.1155/2012/316049. Epub 2012 Jan 19.

Mechanisms of remodeling in asthmatic airways.

Journal of allergy

Adrian Shifren, Chad Witt, Chandrika Christie, Mario Castro

Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

PMID: 22315625 PMCID: PMC3270414 DOI: 10.1155/2012/316049

Abstract

Asthma is a chronic inflammatory airway disorder characterized by airway hyperresponsiveness and reversible airflow obstruction. Subgroups of asthma patients develop airflow obstruction that is irreversible or only partially reversible and experience an accelerated rate of lung function decline. The structural changes in the airways of these patients are referred to as airway remodeling. All elements of the airway wall are involved, and remodeled airway wall thickness is substantially increased compared to normal control airways. Airway remodeling is thought to contribute to the subphenotypes of irreversible airflow obstruction and airway hyperresponsiveness, and it has been associated with increased disease severity. Reversal of remodeling is therefore of paramount therapeutic importance, and mechanisms responsible for airway remodeling are feasible therapeutic targets for asthma treatment. This paper will focus on our current understanding of the mechanisms of airway remodeling in asthma and potential targets for future intervention.

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