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Yeung BH, Wan HT, Law AY, et al. Endocrine disrupting chemicals: Multiple effects on testicular signaling and spermatogenesis. Spermatogenesis. 2011;1(3):231-239doi: 10.4161/spmg.1.3.18019.
Yeung, B. H., Wan, H. T., Law, A. Y., & Wong, C. K. (2011). Endocrine disrupting chemicals: Multiple effects on testicular signaling and spermatogenesis. Spermatogenesis, 1(3), 231-239. https://doi.org/10.4161/spmg.1.3.18019
Yeung, Bonnie Hy, et al. "Endocrine disrupting chemicals: Multiple effects on testicular signaling and spermatogenesis." Spermatogenesis vol. 1,3 (2011): 231-239. doi: https://doi.org/10.4161/spmg.1.3.18019
Yeung BH, Wan HT, Law AY, Wong CK. Endocrine disrupting chemicals: Multiple effects on testicular signaling and spermatogenesis. Spermatogenesis. 2011 Jul;1(3):231-239. doi: 10.4161/spmg.1.3.18019. Epub 2011 Jul 01. PMID: 22319671; PMCID: PMC3271665.
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Spermatogenesis. 2011 Jul;1(3):231-239. doi: 10.4161/spmg.1.3.18019. Epub 2011 Jul 01.

Endocrine disrupting chemicals: Multiple effects on testicular signaling and spermatogenesis.

Spermatogenesis

Bonnie Hy Yeung, Hin T Wan, Alice Ys Law, Chris Kc Wong

Affiliations

  1. Croucher Institute of Environmental Sciences; Department of Biology; Hong Kong Baptist University; Hong Kong.

PMID: 22319671 PMCID: PMC3271665 DOI: 10.4161/spmg.1.3.18019

Abstract

In the past 200 years, an enormous number of synthetic chemicals with diverse structural features have been produced for industrial, medical and domestic purposes. These chemicals, originally thought to have little or no biological toxicity, are widely used in our daily lives as well as are commonly present in foods. It was not until the first World Wildlife Federation Wingspread Conference held in 1994 were concerns about the endocrine disrupting (ED) effects of these chemicals articulated. The potential hazardous effects of endocrine disrupting chemicals (EDCs) on human health and ecological well-being are one of the global concerns that affect the health and propagation of human beings. Considerable numbers of studies indicated that endocrine disruption is linked to "the developmental basis of adult disease," highlighting the significant effects of EDC exposure on a developing organism, leading to the propensity of an individual to develop a disease or dysfunction in later life. In this review, we intend to provide environmental, epidemiological and experimental data to associate pollutant exposure with reproductive disorders, in particular on the development and function of the male reproductive system. Possible effects of pollutant exposure on the processes of embryonic development, like sex determination and masculinization are described. In addition, the effects of pollutant exposure on hypothalamus-pituitary-gonadal axis, testicular signaling, steroidogenesis and spermatogenesis are also discussed.

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