Front Syst Neurosci. 2012 Mar 29;6:19. doi: 10.3389/fnsys.2012.00019. eCollection 2012.
Tinnitus suppression by electric stimulation of the auditory nerve.
Frontiers in systems neuroscience
Janice E Chang, Fan-Gang Zeng
Affiliations
Affiliations
- Department of Anatomy and Neurobiology, University of California Irvine, Irvine CA, USA.
PMID: 22479238
PMCID: PMC3315113 DOI: 10.3389/fnsys.2012.00019
Abstract
Electric stimulation of the auditory nerve via a cochlear implant (CI) has been observed to suppress tinnitus, but parameters of an effective electric stimulus remain unexplored. Here we used CI research processors to systematically vary pulse rate, electrode place, and current amplitude of electric stimuli, and measure their effects on tinnitus loudness and stimulus loudness as a function of stimulus duration. Thirteen tinnitus subjects who used CIs were tested, with nine (70%) being "Responders" who achieved greater than 30% tinnitus loudness reduction in response to at least one stimulation condition and the remaining four (30%) being "Non-Responders" who had less than 30% tinnitus loudness reduction in response to any stimulus condition tested. Despite large individual variability, several interesting observations were made between stimulation parameters, tinnitus characteristics, and tinnitus suppression. If a subject's tinnitus was suppressed by one stimulus, then it was more likely to be suppressed by another stimulus. If the tinnitus contained a "pulsating" component, then it would be more likely suppressed by a given combination of stimulus parameters than tinnitus without these components. There was also a disassociation between the subjects' clinical speech processor and our research processor in terms of their effectiveness in tinnitus suppression. Finally, an interesting dichotomy was observed between loudness adaptation to electric stimuli and their effects on tinnitus loudness, with the Responders exhibiting higher degrees of loudness adaptation than the Non-Responders. Although the mechanisms underlying these observations remain to be resolved, their clinical implications are clear. When using a CI to manage tinnitus, the clinical processor that is optimized for speech perception needs to be customized for optimal tinnitus suppression.
Keywords: cochlear implant; electric stimulation; loudness adaptation; tinnitus
References
- Otol Neurotol. 2011 Jan;32(1):39-47 - PubMed
- Otol Neurotol. 2012 Jan;33(1):6-12 - PubMed
- Otol Neurotol. 2003 May;24(3):478-85 - PubMed
- Otolaryngol Head Neck Surg. 2007 May;136(5):757-62 - PubMed
- Neurosci Biobehav Rev. 2011 Apr;35(5):1089-109 - PubMed
- Ciba Found Symp. 1981;85:204-16 - PubMed
- Int Tinnitus J. 2009;15(1):5-50 - PubMed
- Ann Otol Rhinol Laryngol Suppl. 1995 Sep;166:418-20 - PubMed
- IEEE Rev Biomed Eng. 2008;1:115-42 - PubMed
- Acta Otolaryngol. 1993 May;113(3):291-5 - PubMed
- Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10340-3 - PubMed
- J Am Acad Audiol. 2000 Jun;11(6):293-4 - PubMed
- Prog Brain Res. 2007;166:347-55 - PubMed
- Hear Res. 1999 Jan;127(1-2):108-18 - PubMed
- Am J Audiol. 2009 Dec;18(2):144-51 - PubMed
- J Assoc Res Otolaryngol. 2006 Mar;7(1):59-70 - PubMed
- Laryngoscope. 1994 Jun;104(6 Pt 1):752-4 - PubMed
- J Acoust Soc Am. 2001 Aug;110(2):1150-63 - PubMed
- Hear Res. 2011 Jul;277(1-2):61-6 - PubMed
- J Am Acad Audiol. 2002 Jun;13(6):323-31 - PubMed
- Hear Res. 2011 Jun;276(1-2):52-60 - PubMed
- Ear Hear. 2004 Aug;25(4):310-35 - PubMed
- Ear Hear. 1985 Mar-Apr;6(2):71-5 - PubMed
- J Neurosci. 2010 Nov 10;30(45):14972-9 - PubMed
- Nature. 1991 Jul 18;352(6332):236-8 - PubMed
- Br J Audiol. 2000 Aug;34(4):205-24 - PubMed
- Science. 1994 Apr 22;264(5158):564-6 - PubMed
- Auris Nasus Larynx. 2011 Feb;38(1):14-20 - PubMed
- Arch Otolaryngol Head Neck Surg. 1992 Dec;118(12):1291-7 - PubMed
- Trends Neurosci. 2004 Nov;27(11):676-82 - PubMed
- Int J Audiol. 2004 May;43(5):245-51 - PubMed
- Int Tinnitus J. 1997;3(1):35-38 - PubMed
- J Acoust Soc Am. 1994 Feb;95(2):1085-99 - PubMed
- Brain. 2000 Oct;123 ( Pt 10):2065-76 - PubMed
- Am J Otol. 1990 Jul;11(4):282-9 - PubMed
- Br J Audiol. 1989 Feb;23(1):53-62 - PubMed
- Ann Otol Rhinol Laryngol. 2008 Sep;117(9):645-52 - PubMed
- Trends Amplif. 2004;8(1):1-34 - PubMed
- Hear Res. 2000 Sep;147(1-2):261-74 - PubMed
- J Neuropsychiatry Clin Neurosci. 2009 Spring;21(2):230-1 - PubMed
- Prog Brain Res. 2007;166:237-46 - PubMed
- Otol Neurotol. 2001 Mar;22(2):200-4 - PubMed
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