Display options
Cite
Al-Sader H, Abdul-Jabar H, Allawi Z, et al. Alcohol and breast cancer: the mechanisms explained. J Clin Med Res. 2009;1(3):125-31doi: 10.4021/jocmr2009.07.1246.
Al-Sader, H., Abdul-Jabar, H., Allawi, Z., & Haba, Y. (2009). Alcohol and breast cancer: the mechanisms explained. Journal of clinical medicine research, 1(3), 125-31. https://doi.org/10.4021/jocmr2009.07.1246
Al-Sader, Hassen, et al. "Alcohol and breast cancer: the mechanisms explained." Journal of clinical medicine research vol. 1,3 (2009): 125-31. doi: https://doi.org/10.4021/jocmr2009.07.1246
Al-Sader H, Abdul-Jabar H, Allawi Z, Haba Y. Alcohol and breast cancer: the mechanisms explained. J Clin Med Res. 2009 Aug;1(3):125-31. doi: 10.4021/jocmr2009.07.1246. Epub 2009 Jul 03. PMID: 22493645; PMCID: PMC3318874.
Copy Download .nbib Format: NLM
Share it on

J Clin Med Res. 2009 Aug;1(3):125-31. doi: 10.4021/jocmr2009.07.1246. Epub 2009 Jul 03.

Alcohol and breast cancer: the mechanisms explained.

Journal of clinical medicine research

Hassen Al-Sader, Hani Abdul-Jabar, Zahra Allawi, Yasser Haba

Affiliations

  1. Department of General Medicine, St Georges Hospital, UK.

PMID: 22493645 PMCID: PMC3318874 DOI: 10.4021/jocmr2009.07.1246

Abstract

UNLABELLED: Breast cancer is a leading cause of death amongst women, several studies have shown significant association between alcohol consumption and breast cancer. The aim of this overview is to highlight some of the mechanisms by which alcohol consumption could increase the risk of developing breast cancer. Using online Medline search engine, article containing details about mechanisms which explain the link between alcohol and breast cancer were examined. A number of mechanisms were found by which alcohol could increase the risk of breast cancer, alcohol's interaction and effect on oestrogen secretion; number of oestrogen receptors; the generation of acetaldehyde and hydroxyl free radicals; cells migration and metastasis; secretion of IGF1 and interaction with HRT and folate metabolism. In conclusion, it is essential for clinicians to understand these mechanisms and inform patients of the link between alcohol and breast cancer.

KEYWORDS: Breast cancer; Alcohol; Mechanisms.

References

  1. Alcohol Alcohol. 1990;25(4):341-4 - PubMed
  2. Trends Genet. 1993 Sep;9(9):317-21 - PubMed
  3. Cancer Causes Control. 2001 Dec;12(10):895-902 - PubMed
  4. Alcohol. 2000 Nov;22(3):123-7 - PubMed
  5. Mol Carcinog. 1997 Jan;18(1):19-25 - PubMed
  6. Br J Cancer. 1999 Mar;79(7-8):1308-14 - PubMed
  7. Toxicology. 2001 Mar 7;160(1-3):11-8 - PubMed
  8. JAMA. 1996 Dec 4;276(21):1747-51 - PubMed
  9. Cancer. 1996 May 1;77(9):1831-5 - PubMed
  10. Biochem Biophys Res Commun. 2000 Jul 5;273(2):448-53 - PubMed
  11. Br J Cancer. 2002 Nov 18;87(11):1234-45 - PubMed
  12. Alcohol Alcohol. 1999 Nov-Dec;34(6):894-902 - PubMed
  13. JAMA. 1990 Nov 28;264(20):2648-53 - PubMed
  14. JAMA. 1998 Feb 18;279(7):535-40 - PubMed
  15. Cancer Lett. 2001 Apr 26;165(2):131-7 - PubMed
  16. Am J Epidemiol. 1992 Nov 15;136(10):1221-31 - PubMed
  17. J Endocrinol. 1997 Jan;152(1):39-47 - PubMed
  18. J Gen Intern Med. 1998 Sep;13(9):627-39 - PubMed
  19. Eur J Cancer. 1999 Nov;35(12):1653-8 - PubMed
  20. Alcohol Clin Exp Res. 2003 Mar;27(3):563-75 - PubMed
  21. Ann Oncol. 2005 Mar;16(3):481-8 - PubMed
  22. Cancer Res. 1995 Jan 15;55(2):249-52 - PubMed
  23. J Clin Pathol. 1988 Jan;41(1):3-11 - PubMed
  24. J Stud Alcohol. 1997 Sep;58(5):464-73 - PubMed
  25. Cancer Res. 2001 Oct 1;61(19):7136-41 - PubMed
  26. Int J Cancer. 1998 Aug 21;79(4):334-42 - PubMed
  27. J Clin Endocrinol Metab. 1997 Jun;82(6):1656-8 - PubMed
  28. Alcohol Alcohol. 2004 May-Jun;39(3):155-65 - PubMed
  29. N Engl J Med. 1995 May 11;332(19):1245-50 - PubMed
  30. Cancer Causes Control. 1994 Jan;5(1):53-60 - PubMed
  31. JAMA. 1999 May 5;281(17):1632-7 - PubMed
  32. Cancer. 1989 Aug 1;64(3):591-7 - PubMed
  33. Hepatology. 1998 Jul;28(1):141-9 - PubMed

Publication Types