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Chakravarty AA, Ajmani A, Manchanda S, et al. Incidence of gall stone formation in acromegalic patients on octreotide therapy. Indian J Endocrinol Metab. 2012;16(3):406-8doi: 10.4103/2230-8210.95683.
Chakravarty, A. A., Ajmani, A., Manchanda, S., Kulshreshtha, B., & Chopra, S. (2012). Incidence of gall stone formation in acromegalic patients on octreotide therapy. Indian journal of endocrinology and metabolism, 16(3), 406-8. https://doi.org/10.4103/2230-8210.95683
Chakravarty, Aditi A, et al. "Incidence of gall stone formation in acromegalic patients on octreotide therapy." Indian journal of endocrinology and metabolism vol. 16,3 (2012): 406-8. doi: https://doi.org/10.4103/2230-8210.95683
Chakravarty AA, Ajmani A, Manchanda S, Kulshreshtha B, Chopra S. Incidence of gall stone formation in acromegalic patients on octreotide therapy. Indian J Endocrinol Metab. 2012 May;16(3):406-8. doi: 10.4103/2230-8210.95683. PMID: 22629508; PMCID: PMC3354849.
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Indian J Endocrinol Metab. 2012 May;16(3):406-8. doi: 10.4103/2230-8210.95683.

Incidence of gall stone formation in acromegalic patients on octreotide therapy.

Indian journal of endocrinology and metabolism

Aditi A Chakravarty, Ajay Ajmani, Smita Manchanda, Bindu Kulshreshtha, Shweta Chopra

Affiliations

  1. Department of Endocrinology, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

PMID: 22629508 PMCID: PMC3354849 DOI: 10.4103/2230-8210.95683

Abstract

OBJECTIVE: Octreotide, a long-acting synthetic somatostatin analog, has been widely used for ac-romegalic patients. Gastrointestinal (GI) side effects and gall stones are predominant side effects. We report incidence of gall stones in our cohort of acromegalic patients treated with octreotide therapy.

DESIGN: Retrospective case observational study.

SETTING: Endocrinology Unit, Dr. Ram Manohar Lohia, Hospital, New Delhi.

MATERIALS AND METHODS: Patients of acromegaly on primary or secondary octreotide therapy.

INTERVENTION: Patients were enquired regarding complaints related to the GI system and their medical records were reviewed. Ultrasound films at various intervals while on octerotide therapy were evaluated by the radiologist for presence of sludge and development of gall stones.

RESULTS: Of seven patients, five developed gallstones and sludge was seen in three patients at intervals ranging from 11 to 36 months postoctreotide initiation.

CONCLUSION: A high incidence of gall stone formation in the present study as compared to the West was noted, the reasons for which are not clear.

Keywords: Acromegaly; gall stones; octreotide

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