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Ryan KL, Rickards CA, Hinojosa-Laborde C, et al. Sympathetic responses to central hypovolemia: new insights from microneurographic recordings. Front Physiol. 2012;3:110doi: 10.3389/fphys.2012.00110.
Ryan, K. L., Rickards, C. A., Hinojosa-Laborde, C., Cooke, W. H., & Convertino, V. A. (2012). Sympathetic responses to central hypovolemia: new insights from microneurographic recordings. Frontiers in physiology, 3110. https://doi.org/10.3389/fphys.2012.00110
Ryan, Kathy L, et al. "Sympathetic responses to central hypovolemia: new insights from microneurographic recordings." Frontiers in physiology vol. 3 (2012): 110. doi: https://doi.org/10.3389/fphys.2012.00110
Ryan KL, Rickards CA, Hinojosa-Laborde C, Cooke WH, Convertino VA. Sympathetic responses to central hypovolemia: new insights from microneurographic recordings. Front Physiol. 2012 Apr 26;3:110. doi: 10.3389/fphys.2012.00110. eCollection 2012. PMID: 22557974; PMCID: PMC3337468.
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Front Physiol. 2012 Apr 26;3:110. doi: 10.3389/fphys.2012.00110. eCollection 2012.

Sympathetic responses to central hypovolemia: new insights from microneurographic recordings.

Frontiers in physiology

Kathy L Ryan, Caroline A Rickards, Carmen Hinojosa-Laborde, William H Cooke, Victor A Convertino

Affiliations

  1. U.S. Army Institute of Surgical Research Fort Sam Houston, TX, USA11.

PMID: 22557974 PMCID: PMC3337468 DOI: 10.3389/fphys.2012.00110

Abstract

Hemorrhage remains a major cause of mortality following traumatic injury in both military and civilian settings. Lower body negative pressure (LBNP) has been used as an experimental model to study the compensatory phase of hemorrhage in conscious humans, as it elicits central hypovolemia like that induced by hemorrhage. One physiological compensatory mechanism that changes during the course of central hypovolemia induced by both LBNP and hemorrhage is a baroreflex-mediated increase in muscle sympathetic nerve activity (MSNA), as assessed with microneurography. The purpose of this review is to describe recent results obtained using microneurography in our laboratory as well as those of others that have revealed new insights into mechanisms underlying compensatory increases in MSNA during progressive reductions in central blood volume and how MSNA is altered at the point of hemodynamic decompensation. We will also review recent work that has compared direct MSNA recordings with non-invasive surrogates of MSNA to determine the appropriateness of using such surrogates in assessing the clinical status of hemorrhaging patients.

Keywords: LBNP; MSNA; baroreflex function; central hypovolemia; hemorrhage; sympathetic activity

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