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Muneyyirci-Delale O, Anopa J, Charles C, et al. Medical management of recurrent endometrioma with long-term norethindrone acetate. Int J Womens Health. 2012;4:149-54doi: 10.2147/IJWH.S27819.
Muneyyirci-Delale, O., Anopa, J., Charles, C., Mathur, D., Parris, R., Cutler, J. B., Salame, G., & Abulafia, O. (2012). Medical management of recurrent endometrioma with long-term norethindrone acetate. International journal of women's health, 4149-54. https://doi.org/10.2147/IJWH.S27819
Muneyyirci-Delale, Ozgul, et al. "Medical management of recurrent endometrioma with long-term norethindrone acetate." International journal of women's health vol. 4 (2012): 149-54. doi: https://doi.org/10.2147/IJWH.S27819
Muneyyirci-Delale O, Anopa J, Charles C, Mathur D, Parris R, Cutler JB, Salame G, Abulafia O. Medical management of recurrent endometrioma with long-term norethindrone acetate. Int J Womens Health. 2012;4:149-54. doi: 10.2147/IJWH.S27819. Epub 2012 Mar 30. PMID: 22505834; PMCID: PMC3325007.
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Int J Womens Health. 2012;4:149-54. doi: 10.2147/IJWH.S27819. Epub 2012 Mar 30.

Medical management of recurrent endometrioma with long-term norethindrone acetate.

International journal of women's health

Ozgul Muneyyirci-Delale, Jenny Anopa, Cassandra Charles, Deepali Mathur, Rudolph Parris, Jed B Cutler, Ghadir Salame, Ovadia Abulafia

Affiliations

  1. Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, New York, NY, USA.

PMID: 22505834 PMCID: PMC3325007 DOI: 10.2147/IJWH.S27819

Abstract

PURPOSE: Evaluate the efficacy of norethindrone acetate in the resolution of symptoms and regression of recurrent endometrioma.

PATIENTS AND METHODS: Retrospective chart review at SUNY Downstate Medical Center of patients with a history of surgical excision of endometrioma (with histological confirmation) and recurrent endometrioma (demonstrated by strict sonographic criterion of endometrioma) who were willing to undergo follow-up. Patients were prescribed norethindrone acetate to be taken daily with follow-up sonograms until cysts regressed. Statistical analysis included Student's t-test and a simple linear regression model to assess cyst regression over time during treatment.

RESULTS: Degree of pain was significantly lower on treatment when compared to baseline (P < 0.00001). Cyst size was significantly smaller in as little as 3 months (P < 0.0001). Average rate of regression with continuous treatment was 0.025 ± 0.015 cm/day. Total mean ± standard deviation regression time is 10.28 ± 8.25 months.

CONCLUSION: Norethindrone acetate was effective in eradicating symptoms and producing complete regression of recurrent endometriomas. It should be considered for patients who are likely to adhere to a prolonged treatment regimen and comply with recommendations for surveillance with serial sonograms.

Keywords: dysmenorrhea; endometriosis; medical therapy; regression

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