Display options
Cite
Benke D, Zemoura K, Maier PJ. Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation. World J Biol Chem. 2012;3(4):61-72doi: 10.4331/wjbc.v3.i4.61.
Benke, D., Zemoura, K., & Maier, P. J. (2012). Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation. World journal of biological chemistry, 3(4), 61-72. https://doi.org/10.4331/wjbc.v3.i4.61
Benke, Dietmar, et al. "Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation." World journal of biological chemistry vol. 3,4 (2012): 61-72. doi: https://doi.org/10.4331/wjbc.v3.i4.61
Benke D, Zemoura K, Maier PJ. Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation. World J Biol Chem. 2012 Apr 26;3(4):61-72. doi: 10.4331/wjbc.v3.i4.61. PMID: 22558486; PMCID: PMC3342575.
Copy Download .nbib Format: NLM
Share it on

World J Biol Chem. 2012 Apr 26;3(4):61-72. doi: 10.4331/wjbc.v3.i4.61.

Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation.

World journal of biological chemistry

Dietmar Benke, Khaled Zemoura, Patrick J Maier

Affiliations

  1. Dietmar Benke, Khaled Zemoura, Patrick J Maier, Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

PMID: 22558486 PMCID: PMC3342575 DOI: 10.4331/wjbc.v3.i4.61

Abstract

Inhibitory neurotransmission ensures normal brain function by counteracting and integrating excitatory activity. γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system, and mediates its effects via two classes of receptors: the GABA(A) and GABA(B) receptors. GABA(A) receptors are heteropentameric GABA-gated chloride channels and responsible for fast inhibitory neurotransmission. GABA(B) receptors are heterodimeric G protein coupled receptors (GPCR) that mediate slow and prolonged inhibitory transmission. The extent of inhibitory neurotransmission is determined by a variety of factors, such as the degree of transmitter release and changes in receptor activity by posttranslational modifications (e.g., phosphorylation), as well as by the number of receptors present in the plasma membrane available for signal transduction. The level of GABA(B) receptors at the cell surface critically depends on the residence time at the cell surface and finally the rates of endocytosis and degradation. In this review we focus primarily on recent advances in the understanding of trafficking mechanisms that determine the expression level of GABA(B) receptors in the plasma membrane, and thereby signaling strength.

Keywords: Degradation; Endocytosis; GABAB receptors; Neuron; Recycling; Trafficking

References

  1. Anesthesiology. 2011 Feb;114(2):401-11 - PubMed
  2. J Neurosci. 2006 Apr 19;26(16):4289-97 - PubMed
  3. Nat Neurosci. 2002 May;5(5):415-24 - PubMed
  4. Nature. 2000 Nov 30;408(6812):589-93 - PubMed
  5. J Neurosci. 1998 Mar 1;18(5):1913-22 - PubMed
  6. Neuropharmacology. 2005 Mar;48(3):343-53 - PubMed
  7. J Biol Chem. 2007 Aug 17;282(33):24157-65 - PubMed
  8. Eur J Neurosci. 2006 Mar;23(6):1479-90 - PubMed
  9. Biochimie. 2005 Jan;87(1):87-91 - PubMed
  10. Biochem Biophys Res Commun. 1995 Jul 26;212(3):1022-8 - PubMed
  11. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14649-54 - PubMed
  12. Neuroscience. 2005;136(4):1083-95 - PubMed
  13. Nature. 2010 Jan 28;463(7280):464-73 - PubMed
  14. J Neurochem. 2008 Oct;107(1):86-95 - PubMed
  15. J Neurosci. 2004 Jul 7;24(27):6115-26 - PubMed
  16. Curr Opin Neurobiol. 2011 Apr;21(2):339-44 - PubMed
  17. Neuron. 2000 Jul;27(1):97-106 - PubMed
  18. J Biol Chem. 1998 Oct 9;273(41):26361-7 - PubMed
  19. J Biol Chem. 1999 Mar 19;274(12):7607-10 - PubMed
  20. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14643-8 - PubMed
  21. Neuron. 1997 Sep;19(3):687-95 - PubMed
  22. Neurochem Int. 1997 Jul;31(1):21-5 - PubMed
  23. Pharmacol Rev. 2001 Mar;53(1):1-24 - PubMed
  24. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1118-22 - PubMed
  25. Science. 1986 Dec 5;234(4781):1261-5 - PubMed
  26. Neuropharmacology. 2009 Jun;56(8):1088-96 - PubMed
  27. Science. 1999 Jan 1;283(5398):74-7 - PubMed
  28. J Physiol. 1995 May 15;485 ( Pt 1):29-42 - PubMed
  29. Neuroscience. 1996 Jan;70(2):417-27 - PubMed
  30. J Neurosci. 2003 Dec 3;23(35):11026-35 - PubMed
  31. Neuron. 1999 Dec;24(4):979-88 - PubMed
  32. J Physiol. 1996 Apr 1;492 ( Pt 1):115-27 - PubMed
  33. J Biol Chem. 1999 May 7;274(19):13362-9 - PubMed
  34. J Cell Physiol. 2007 Jan;210(1):237-45 - PubMed
  35. EMBO J. 2001 May 1;20(9):2152-9 - PubMed
  36. Curr Opin Neurobiol. 2007 Jun;17(3):298-303 - PubMed
  37. Neuron. 1997 Apr;18(4):651-63 - PubMed
  38. EMBO J. 2006 Jun 21;25(12):2698-709 - PubMed
  39. Mol Biol Cell. 2005 Dec;16(12):5572-8 - PubMed
  40. Physiol Genomics. 2005 Jun 16;22(1):93-8 - PubMed
  41. Pflugers Arch. 2005 Apr;450(1):61-73 - PubMed
  42. Eur J Neurosci. 2004 Jun;19(12):3227-34 - PubMed
  43. J Biol Chem. 2004 Apr 16;279(16):15824-30 - PubMed
  44. J Physiol. 1993 Oct;470:1-11 - PubMed
  45. Nature. 1997 Mar 20;386(6622):239-46 - PubMed
  46. Brain Res. 1999 Nov 20;847(2):175-85 - PubMed
  47. Neuron. 2009 Mar 26;61(6):917-29 - PubMed
  48. Prog Neurobiol. 2008 Nov;86(3):297-303 - PubMed
  49. Nature. 2010 May 13;465(7295):231-5 - PubMed
  50. Nature. 1998 Dec 17;396(6712):683-7 - PubMed
  51. J Biol Chem. 2004 Jul 9;279(28):29085-91 - PubMed
  52. Nature. 1980 Jan 3;283(5742):92-4 - PubMed
  53. EMBO J. 2003 Aug 1;22(15):3816-24 - PubMed
  54. J Med Chem. 2001 Jan 4;44(1):27-35 - PubMed
  55. J Biol Chem. 2008 Sep 5;283(36):24641-8 - PubMed
  56. Eur J Neurosci. 2009 Mar;29(5):869-78 - PubMed
  57. J Biol Chem. 2004 Mar 26;279(13):12565-73 - PubMed
  58. J Neurochem. 2008 Apr;105(2):308-23 - PubMed
  59. Endocrinology. 1998 Jun;139(6):2784-95 - PubMed
  60. Curr Opin Cell Biol. 2007 Aug;19(4):417-25 - PubMed
  61. Neuropharmacology. 2005 Jun;48(7):956-64 - PubMed
  62. Eur J Neurosci. 2007 Mar;25(5):1402-16 - PubMed
  63. J Biol Chem. 2008 Dec 12;283(50):34745-52 - PubMed
  64. Mol Cell Neurosci. 2008 Dec;39(4):628-37 - PubMed
  65. J Comp Neurol. 2004 Jun 28;474(3):340-52 - PubMed
  66. J Biol Chem. 2010 Nov 12;285(46):35606-14 - PubMed
  67. J Neurochem. 2008 Dec;107(6):1506-17 - PubMed
  68. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13918-23 - PubMed
  69. Nature. 1989 Jul 13;340(6229):153-6 - PubMed
  70. Nature. 2009 Mar 26;458(7237):445-52 - PubMed
  71. FEBS Lett. 1990 Oct 1;271(1-2):231-5 - PubMed
  72. Neuron. 2007 Jan 18;53(2):233-47 - PubMed
  73. Nature. 1998 Dec 17;396(6712):674-9 - PubMed
  74. Neuron. 2010 Jul 29;67(2):253-67 - PubMed
  75. J Biol Chem. 2002 Feb 1;277(5):3236-41 - PubMed
  76. FEBS Lett. 2010 Aug 4;584(15):3317-22 - PubMed
  77. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13924-9 - PubMed
  78. J Biol Chem. 2009 May 8;284(19):13077-85 - PubMed
  79. Nat Rev Mol Cell Biol. 2009 Sep;10(9):623-35 - PubMed
  80. Neurosci Lett. 1990 Oct 2;118(1):9-13 - PubMed
  81. Nat Neurosci. 2004 Feb;7(2):153-9 - PubMed
  82. Pflugers Arch. 1993 Nov;425(3-4):335-43 - PubMed
  83. Nature. 1998 Dec 17;396(6712):679-82 - PubMed
  84. Eur J Pharmacol. 2003 Nov 14;481(1):15-23 - PubMed
  85. Annu Rev Neurosci. 2004;27:107-44 - PubMed
  86. Eur J Neurosci. 2003 Dec;18(12):3279-93 - PubMed
  87. Nature. 1994 Jul 14;370(6485):143-6 - PubMed
  88. Neuron. 1995 Nov;15(5):1133-43 - PubMed
  89. Neuron. 2006 May 18;50(4):603-16 - PubMed
  90. J Neurochem. 2009 Aug;110(4):1363-76 - PubMed
  91. Science. 2004 Sep 24;305(5692):1972-5 - PubMed
  92. Neuron. 2006 May 18;50(4):589-601 - PubMed
  93. Neuron. 2010 Apr 15;66(1):101-13 - PubMed
  94. Cell Metab. 2005 Jan;1(1):15-25 - PubMed
  95. Nature. 1994 Mar 17;368(6468):255-7 - PubMed
  96. Mol Pharmacol. 2005 Jul;68(1):137-44 - PubMed
  97. Neuroscientist. 2012 Jun;18(3):237-50 - PubMed
  98. J Comp Neurol. 2004 Jul 12;475(1):36-46 - PubMed
  99. Mol Pharmacol. 2002 Aug;62(2):343-50 - PubMed
  100. Neuroscientist. 2008 Dec;14(6):598-608 - PubMed
  101. J Neurosci. 2001 Feb 15;21(4):1203-10 - PubMed
  102. FASEB J. 2000 Dec;14(15):2569-80 - PubMed
  103. Neuron. 2000 Mar;25(3):673-81 - PubMed
  104. Nature. 2003 Aug 14;424(6950):775-8 - PubMed
  105. Neurosci Lett. 2001 Jan 12;297(2):137-41 - PubMed
  106. J Neurosci. 2001 Oct 15;21(20):8043-52 - PubMed
  107. J Neurosci. 2001 Feb 15;21(4):1189-202 - PubMed
  108. J Biol Chem. 2000 Dec 29;275(52):41166-74 - PubMed
  109. Mol Cell Biochem. 2010 Oct;343(1-2):1-11 - PubMed
  110. Neuron. 1993 May;10(5):889-98 - PubMed

Publication Types