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Nwose EU, Richards RS. Whole blood viscosity issues VII: The correlation with leucocytosis and implication on leukapheresis. N Am J Med Sci. 2010;2(12):576-9doi: 10.4297/najms.2010.2576.
Nwose, E. U., & Richards, R. S. (2010). Whole blood viscosity issues VII: The correlation with leucocytosis and implication on leukapheresis. North American journal of medical sciences, 2(12), 576-9. https://doi.org/10.4297/najms.2010.2576
Nwose, Ezekiel Uba, and Richards, Ross Stuart. "Whole blood viscosity issues VII: The correlation with leucocytosis and implication on leukapheresis." North American journal of medical sciences vol. 2,12 (2010): 576-9. doi: https://doi.org/10.4297/najms.2010.2576
Nwose EU, Richards RS. Whole blood viscosity issues VII: The correlation with leucocytosis and implication on leukapheresis. N Am J Med Sci. 2010 Dec;2(12):576-9. doi: 10.4297/najms.2010.2576. PMID: 22558570; PMCID: PMC3338225.
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N Am J Med Sci. 2010 Dec;2(12):576-9. doi: 10.4297/najms.2010.2576.

Whole blood viscosity issues VII: The correlation with leucocytosis and implication on leukapheresis.

North American journal of medical sciences

Ezekiel Uba Nwose, Ross Stuart Richards

Affiliations

  1. South West Pathology Service, 590 Smollett Street Albury, NSW 2640, Australia.

PMID: 22558570 PMCID: PMC3338225 DOI: 10.4297/najms.2010.2576

Abstract

BACKGROUND: Blood hyperviscosity has been acknowledged to be a complicating factor in polycythaemia and hyperproteinaemia. Hyperleucocytosis has also been implicated in hyperviscosity and may be a basis for therapeutic leukapheresis.

AIMS: This issue in the series seeks to determine the association and correlation between whole blood viscosity and white blood cell count (WBCC), with a view to advance the cause of a neglected clinical pathology index. MATERIALS #ENTITYSTARTX00026;

METHODS: Based on archived clinical pathology data, 10,857 cases that were concomitantly tested for full blood count and total proteins in the 2008 calendar year were audited for hyperleucocytosis. Whole blood viscosity level was determined and compared in the group with leucocytosis relative to the group with leucopenia and normal WBCC. The confounding effects of age, gender and red blood cell indices were evaluated. The correlation between whole blood viscosity and WBCC was also determined.

RESULTS: As a generalization, hypoviscosity is observed among individuals who presented hyperleucocytosis. There is no correlation (r = 0.20) between leucocytosis and blood viscosity.

CONCLUSION: It is known that anaemia and thromboembolism, which can be associated with leucocytosis, predispose to hypoviscosity. The finding from this study provides evidence of association between hypoviscosity and leucocytosis. The absence of association and insignificant correlation between leucocytosis and hyperviscosity may be one explanation for ineffectiveness of therapeutic leukapheresis. Further, the non-correlation lends credence to specificity of blood viscosity, for which critical leucocytosis is not a substitute.

Keywords: Clinical laboratory; evidence-based practice; hyperleucocytosis; leukapheresis; whole blood viscosity

References

  1. Ann Acad Med Singap. 2005 Apr;34(3):229-34 - PubMed
  2. J Child Neurol. 2008 Nov;23(11):1347-52 - PubMed
  3. Haematologica. 2009 Nov;94(11):1481-4 - PubMed
  4. Semin Thromb Hemost. 2003 Oct;29(5):535-42 - PubMed
  5. Br J Haematol. 1997 Jan;96(1):168-73 - PubMed
  6. N Am J Med Sci. 2010 Apr;2(4):165-9 - PubMed
  7. Acta Med Indones. 2009 Oct;41(4):200-4 - PubMed
  8. N Am J Med Sci. 2010 Jun;2(6):252-7 - PubMed
  9. Blood. 2007 Aug 1;110(3):908-12 - PubMed
  10. Curr Vasc Pharmacol. 2010 Jul;8(4):482-94 - PubMed
  11. Am J Epidemiol. 2008 Nov 15;168(10):1153-60 - PubMed
  12. Semin Thromb Hemost. 2003 Oct;29(5):459-65 - PubMed
  13. Br J Clin Pharmacol. 2002 Jul;54(1):96-100 - PubMed
  14. Semin Thromb Hemost. 2007 Jun;33(4):350-4 - PubMed

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