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Int J Alzheimers Dis. 2012;2012:253153. doi: 10.1155/2012/253153. Epub 2012 Feb 12.

Specific EEG changes associated with atrophy of hippocampus in subjects with mild cognitive impairment and Alzheimer's disease.

International journal of Alzheimer's disease

D V Moretti, A Prestia, C Fracassi, G Binetti, O Zanetti, G B Frisoni

Affiliations

  1. IRCCS Centro S. Giovanni Di Dio Fatebenefratelli, 25125 Brescia, Italy.

PMID: 22506130 PMCID: PMC3296269 DOI: 10.1155/2012/253153

Abstract

We evaluated the association between hippocampal atrophy and increase of the EEG markers alpha3/alpha2 relative power ratio in mild cognitive impairment (MCI) and Alzheimer's disease patients. Seventy-nine subjects with MCI and 11 patients with AD underwent EEG recording and MRI scan. The MCI group was subdivided in three subgroups according to growing hippocampal atrophy. The groups were characterized by alpha3/alpha2 relative power ratio. In AD patients group mapped hippocampal regions were computed and related with alpha3/alpha2 power ratio. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of hippocampus both in MCI and in Alzheimer's disease patients. This finding confirms the possible diagnostic role of EEG markers as diagnostic and prognostic factors in patient with prodromal and declared Alzheimer's disease.

References

  1. J Psychiatr Res. 1975 Nov;12(3):189-98 - PubMed
  2. Neurosci Lett. 2004 Jan 9;354(2):123-6 - PubMed
  3. Neuroimage. 1999 Sep;10(3 Pt 1):269-81 - PubMed
  4. Neuroscience. 2006 Sep 29;142(1):1-20 - PubMed
  5. Neurology. 1984 Jul;34(7):939-44 - PubMed
  6. Funct Neurol. 1987 Apr-Jun;2(2):189-94 - PubMed
  7. Arch Neurol. 2001 Dec;58(12):1985-92 - PubMed
  8. Trends Neurosci. 1998 Jul;21(7):294-9 - PubMed
  9. J Neurosci. 2001 May 15;21(10):3697-703 - PubMed
  10. Brain Res Brain Res Rev. 1999 Apr;29(2-3):169-95 - PubMed
  11. Int J Geriatr Psychiatry. 2000 Jun;15(6):548-61 - PubMed
  12. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4034-9 - PubMed
  13. Clin Neurophysiol. 2007 Dec;118(12):2716-29 - PubMed
  14. Arch Gen Psychiatry. 2006 Jan;63(1):57-62 - PubMed
  15. Neurocase. 2005 Feb;11(1):80-4 - PubMed
  16. Cereb Cortex. 2000 Apr;10(4):433-42 - PubMed
  17. J Alzheimers Dis. 2009;17(2):349-57 - PubMed
  18. Neurology. 1997 Sep;49(3):786-94 - PubMed
  19. Dement Geriatr Cogn Disord. 1999 Jul-Aug;10(4):284-8 - PubMed
  20. Aging Clin Exp Res. 2002 Apr;14(2):117-31 - PubMed
  21. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14495-500 - PubMed
  22. Lancet. 1999 Jan 2;353(9146):38-40 - PubMed
  23. Cereb Cortex. 1998 Sep;8(6):492-509 - PubMed
  24. Trends Cogn Sci. 2002 Jul 1;6(7):306-314 - PubMed
  25. Int J Psychophysiol. 1997 Jun;26(1-3):237-49 - PubMed
  26. Lancet Neurol. 2003 Jan;2(1):15-21 - PubMed
  27. Lancet Neurol. 2007 Aug;6(8):734-46 - PubMed
  28. Int J Alzheimers Dis. 2011;2011:208218 - PubMed
  29. Gerontologist. 1969 Autumn;9(3):179-86 - PubMed
  30. J Neurol Neurosurg Psychiatry. 2006 Jun;77(6):714-8 - PubMed
  31. Ann N Y Acad Sci. 2007 Feb;1097:146-55 - PubMed
  32. Neurosci Lett. 1999 Jul 30;270(2):83-6 - PubMed
  33. Prog Brain Res. 2000;126:29-37 - PubMed
  34. Neurol Sci. 2002 Mar;22(6):443-7 - PubMed
  35. Neurosci Lett. 2002 May 17;324(2):121-4 - PubMed
  36. Eur J Neurosci. 2006 Jul;24(1):135-44 - PubMed
  37. Brain. 2008 Dec;131(Pt 12):3266-76 - PubMed
  38. Br J Psychiatry. 1982 Jun;140:566-72 - PubMed
  39. JAMA. 1995 Apr 26;273(16):1274-8 - PubMed
  40. J Neurophysiol. 1995 Nov;74(5):2201-3 - PubMed
  41. Int J Neurosci. 1991 Apr;57(3-4):167-78 - PubMed
  42. J Neurosci. 2000 Apr 1;20(7):2701-10 - PubMed
  43. Brain. 2007 Mar;130(Pt 3):720-30 - PubMed
  44. Neuroimage. 2004 Apr;21(4):1563-75 - PubMed
  45. Neuroscience. 2011 Jul 28;187:52-62 - PubMed
  46. Eur Neurol. 1996;36(6):378-84 - PubMed
  47. Neuroimage. 2012 Feb 1;59(3):2155-66 - PubMed
  48. Neuroimage. 1996 Feb;3(1):19-34 - PubMed
  49. J Alzheimers Dis. 2008 Jul;14(3):285-99 - PubMed
  50. Learn Mem. 2002 May-Jun;9(3):99-104 - PubMed
  51. Brain Res Rev. 2007 Jan;53(1):63-88 - PubMed
  52. Biol Psychiatry. 2000 Mar 15;47(6):557-61 - PubMed
  53. Brain Res. 1994 Sep 5;656(1):157-64 - PubMed
  54. Int Psychogeriatr. 1997;9 Suppl 1:65-9 - PubMed
  55. Clin Neurophysiol. 2011 Dec;122(12):2488-97 - PubMed
  56. J Neurol Neurosurg Psychiatry. 2001 Oct;71(4):441-7 - PubMed
  57. Clin Neurophysiol. 2004 Feb;115(2):299-308 - PubMed
  58. Neuroimage. 2006 Aug 1;32(1):104-10 - PubMed
  59. CNS Spectr. 2008 Jan;13(1):45-53 - PubMed
  60. Conf Proc IEEE Eng Med Biol Soc. 2006;2006:4979-82 - PubMed
  61. J Neurol. 2009 Jun;256(6):916-24 - PubMed
  62. Ann Neurol. 1980 May;7(5):486-8 - PubMed
  63. Eur J Neurosci. 2010 Jun;31(12):2292-307 - PubMed
  64. J Neurol Neurosurg Psychiatry. 2006 Nov;77(11):1219-22 - PubMed
  65. Hippocampus. 2011 Sep;21(9):923-8 - PubMed
  66. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2016-20 - PubMed
  67. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8477-81 - PubMed
  68. Neurocase. 2005 Feb;11(1):85-92 - PubMed

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