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Inyang-Etoh EC, Agan TU, Etuk SJ, et al. The role of prophylactic antimalarial in the reduction of placental parasitemia among pregnant women in Calabar, Nigeria. Niger Med J. 2011;52(4):235-8doi: 10.4103/0300-1652.93795.
Inyang-Etoh, E. C., Agan, T. U., Etuk, S. J., & Inyang-Etoh, P. C. (2011). The role of prophylactic antimalarial in the reduction of placental parasitemia among pregnant women in Calabar, Nigeria. Nigerian medical journal : journal of the Nigeria Medical Association, 52(4), 235-8. https://doi.org/10.4103/0300-1652.93795
Inyang-Etoh, Emmanuel Columba, et al. "The role of prophylactic antimalarial in the reduction of placental parasitemia among pregnant women in Calabar, Nigeria." Nigerian medical journal : journal of the Nigeria Medical Association vol. 52,4 (2011): 235-8. doi: https://doi.org/10.4103/0300-1652.93795
Inyang-Etoh EC, Agan TU, Etuk SJ, Inyang-Etoh PC. The role of prophylactic antimalarial in the reduction of placental parasitemia among pregnant women in Calabar, Nigeria. Niger Med J. 2011 Oct;52(4):235-8. doi: 10.4103/0300-1652.93795. PMID: 22529505; PMCID: PMC3329092.
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Niger Med J. 2011 Oct;52(4):235-8. doi: 10.4103/0300-1652.93795.

The role of prophylactic antimalarial in the reduction of placental parasitemia among pregnant women in Calabar, Nigeria.

Nigerian medical journal : journal of the Nigeria Medical Association

Emmanuel Columba Inyang-Etoh, Thomas Udagbor Agan, Saturday Job Etuk, Paul Columba Inyang-Etoh

Affiliations

  1. Department of Obstetrics and Gynaecology, University of Uyo, Uyo, Akwa Ibom State, Nigeria.

PMID: 22529505 PMCID: PMC3329092 DOI: 10.4103/0300-1652.93795

Abstract

INTRODUCTION: Intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine is a recommendation of the World Health Organization as part of the malaria control strategy in pregnancy in areas with malaria burden.

AIM: This study set out to appraise the effectiveness of this regimen in the prevention of placental parasitemia among parturients in Calabar, Nigeria.

MATERIALS AND METHODS: Pretested, precoded questionnaires were administered to eligible women at the antenatal clinic and later updated at the labor ward. Intermittent preventive treatment was administered under direct observation at the clinic, while packed cell volume, placental parasitemia, and other laboratory tests were measured at the labor ward.

RESULTS: The gross presence of placental malaria in the intermittent preventive treatment (IPT)-treated and the control groups was 10.6% and 11.3% respectively (P=0.76). Anemia occurred in 3.1% of the IPT-treated group compared to 11.7% among the control group (P=0.000). Only 7.9% of the IPT-treated women had moderate to severe placental parsitemia whereas as many as 53.2% of women in the control group had moderate to severe parasitemia (P=0.000).

CONCLUSION: Intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine was associated with significant reduction in the degree of placental parasitemia among women in the IPT-treated group, although it did not completely eradicate placental malaria in the treatment group.

Keywords: Intermittent preventive treatment; malaria in pregnancy; placental parasitemia

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