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Mol Cell. 2012 May 25;46(4):382-3. doi: 10.1016/j.molcel.2012.05.010.

Lifting the threshold between life and death: SUMO and HDAC fine-tune HIPK2 to sense redox status.

Molecular cell

Susanna Chiocca, Christian Seiser

Affiliations

  1. European Institute of Oncology, Department of Experimental Oncology, IFOM-IEO Campus, Milan, Italy. [email protected]

PMID: 22633485 DOI: 10.1016/j.molcel.2012.05.010

Abstract

In the current issue of Molecular Cell, de la Vega et al. (2012) propose an intriguing model for HIPK2 posttranslational modifications in response to oxidative stress, explaining how HIPK2 can possess both prosurvival as well as proapoptotic activities.

Copyright © 2012 Elsevier Inc. All rights reserved.

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