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Rao BH, Rai G, Hassan S, et al. Ewing's sarcoma of the mandible. Natl J Maxillofac Surg. 2011;2(2):184-8doi: 10.4103/0975-5950.94479.
Rao, B. H., Rai, G., Hassan, S., & Nadaf, A. (2011). Ewing's sarcoma of the mandible. National journal of maxillofacial surgery, 2(2), 184-8. https://doi.org/10.4103/0975-5950.94479
Rao, B H Sripathi, et al. "Ewing's sarcoma of the mandible." National journal of maxillofacial surgery vol. 2,2 (2011): 184-8. doi: https://doi.org/10.4103/0975-5950.94479
Rao BH, Rai G, Hassan S, Nadaf A. Ewing's sarcoma of the mandible. Natl J Maxillofac Surg. 2011 Jul;2(2):184-8. doi: 10.4103/0975-5950.94479. PMID: 22639511; PMCID: PMC3343390.
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Natl J Maxillofac Surg. 2011 Jul;2(2):184-8. doi: 10.4103/0975-5950.94479.

Ewing's sarcoma of the mandible.

National journal of maxillofacial surgery

B H Sripathi Rao, Gunachander Rai, Shahid Hassan, Afreen Nadaf

Affiliations

  1. Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Mangalore, India.

PMID: 22639511 PMCID: PMC3343390 DOI: 10.4103/0975-5950.94479

Abstract

Ewing's sarcoma is a malignant tumor of bones that primarily affects children and young adults. The true origin of this small round cell lesion still remains controversial. It was originally described by James Ewing in 1921 as arising from undifferentiated osseous mesenchymal cells; however, recent studies suggest that Ewing's tumor might be neuroectodermally derived from various degrees of differentiation of the primitive neural tissues. This paper reports a rare case of ES of the mandible in an 11-year-old girl, which had been previously misdiagnosed and treated as a dental abscess. In the clinical examination, a hard immobile expansive mass of 2 cm diameter was observed on the left side of the mandible. Radiographic examination revealed a diffuse radiolucent lesion with ill-defined borders and wide vestibular bone plate destruction. Microscopically, the tumor was composed by monotonous small round cells that exhibited immunoreactivity for CD99, vimentin and desmin. Surgical resection of mandible followed by mandibular reconstruction was adopted. The patient was subjected to multiagent chemotherapy with Vincristine [VC], Dactinomycin [AC], Cyclophosphamide [CP] and Doxorubicin [AD]).

Keywords: Child; Ewing's sarcoma; diagnosis; immunohistochemistry; mandible

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