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Sztefko K, Szybowska P. Interpretation of hormone levels in older patients: points for consideration. Int J Endocrinol. 2012;2012:712425doi: 10.1155/2012/712425.
Sztefko, K., & Szybowska, P. (2012). Interpretation of hormone levels in older patients: points for consideration. International journal of endocrinology, 2012712425. https://doi.org/10.1155/2012/712425
Sztefko, Krystyna, and Szybowska, Patrycja. "Interpretation of hormone levels in older patients: points for consideration." International journal of endocrinology vol. 2012 (2012): 712425. doi: https://doi.org/10.1155/2012/712425
Sztefko K, Szybowska P. Interpretation of hormone levels in older patients: points for consideration. Int J Endocrinol. 2012;2012:712425. doi: 10.1155/2012/712425. Epub 2012 May 14. PMID: 22666247; PMCID: PMC3359804.
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Int J Endocrinol. 2012;2012:712425. doi: 10.1155/2012/712425. Epub 2012 May 14.

Interpretation of hormone levels in older patients: points for consideration.

International journal of endocrinology

Krystyna Sztefko, Patrycja Szybowska

Affiliations

  1. Clinical Biochemistry Department, College of Medicine, Jagiellonian University, Wielicka Street 265, 30-663 Kracow, Poland.

PMID: 22666247 PMCID: PMC3359804 DOI: 10.1155/2012/712425

Abstract

Blood hormone and tumor marker concentrations are usually determined by immunochemical methods which are based on an unique reaction between antigen and assay capture antibody. Despite the speed and simplicity of assays performance on automatic immunochemistry platforms, the interpretation of final results requires a deep knowledge of method fallibility. General lack of immunoassays standardization, presence of cross-reacting substances in patient's sample, limitation of free hormones measurement due to abnormal analyte binding protein concentrations, assay interferences due to patient's autoantibodies, and heterophilic antibodies, as well as proper interpretation of very low- and very high-sample analyte levels, are the main points discussed in respect to hormones and tumor markers measurement in geriatric population.

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