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Pritchett JC, Nanau RM, Neuman MG. The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation. Int J Hepatol. 2012;2012:723062doi: 10.1155/2012/723062.
Pritchett, J. C., Nanau, R. M., & Neuman, M. G. (2012). The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation. International journal of hepatology, 2012723062. https://doi.org/10.1155/2012/723062
Pritchett, Joshua C, et al. "The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation." International journal of hepatology vol. 2012 (2012): 723062. doi: https://doi.org/10.1155/2012/723062
Pritchett JC, Nanau RM, Neuman MG. The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation. Int J Hepatol. 2012;2012:723062. doi: 10.1155/2012/723062. Epub 2012 May 16. PMID: 22666603; PMCID: PMC3362035.
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Int J Hepatol. 2012;2012:723062. doi: 10.1155/2012/723062. Epub 2012 May 16.

The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation.

International journal of hepatology

Joshua C Pritchett, Radu M Nanau, Manuela G Neuman

Affiliations

  1. HHV-6 Foundation, Santa Barbara, CA 93108, USA.

PMID: 22666603 PMCID: PMC3362035 DOI: 10.1155/2012/723062

Abstract

Background. There are challenges in the clinical diagnosis of drug-induced injury and in obtaining information on the reactivation of human herpes viruses (HHV) during idiosyncratic adverse drug reactions. Objectives. (i) To develop a unified list of drugs incriminated in drug-induced hepatotoxicity and severe cutaneous reactions, in which drug hypersensitivity leads to HHV-6 reactivation and further complication of therapy and recovery and (ii) to supplement the already available data on reporting frequencies of liver- or skin-induced cases with knowledge of individual case reports, including HHV-6 reactivation and briefly introducing chromosomally integrated HHV-6. Data Sources and Extraction. Drugs identified as causes of (i) idiosyncratic reactions, (ii) drug-induced hypersensitivity, drug-induced hepatotoxicity, acute liver failure, and Stevens-Johnson syndrome, and (iii) human herpes virus reactivation in PubMed since 1997 have been collected and discussed. Results. Data presented in this paper show that HHV-6 reactivation is associated with more severe organ involvement and a prolonged course of disease. Conclusion. This analysis of HHV-6 reactivation associated with drug-induced severe cutaneous reactions and hepatotoxicity will aid in causality assessment and clinical diagnosis of possible life-threatening events and will provide a basis for further patient characterization and therapy.

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