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Ahmed K, Jeong MH, Chakraborty R, et al. Clinical impact of non-high density lipoprotein-cholesterol and apolipoprotein B on clinical outcomes in metabolic syndrome patients with acute myocardial infarction undergoing percutaneous coronary intervention. Korean Circ J. 2012;42(5):319-28doi: 10.4070/kcj.2012.42.5.319.
Ahmed, K., Jeong, M. H., Chakraborty, R., Hong, Y. J., Oh, M. S., Cho, K. H., Kim, M. C., Hachinohe, D., Hwang, S. H., Lee, M. G., Sim, D. S., Park, K. H., Kim, J. H., Ahn, Y., & Kang, J. C. (2012). Clinical impact of non-high density lipoprotein-cholesterol and apolipoprotein B on clinical outcomes in metabolic syndrome patients with acute myocardial infarction undergoing percutaneous coronary intervention. Korean circulation journal, 42(5), 319-28. https://doi.org/10.4070/kcj.2012.42.5.319
Ahmed, Khurshid, et al. "Clinical impact of non-high density lipoprotein-cholesterol and apolipoprotein B on clinical outcomes in metabolic syndrome patients with acute myocardial infarction undergoing percutaneous coronary intervention." Korean circulation journal vol. 42,5 (2012): 319-28. doi: https://doi.org/10.4070/kcj.2012.42.5.319
Ahmed K, Jeong MH, Chakraborty R, Hong YJ, Oh MS, Cho KH, Kim MC, Hachinohe D, Hwang SH, Lee MG, Sim DS, Park KH, Kim JH, Ahn Y, Kang JC. Clinical impact of non-high density lipoprotein-cholesterol and apolipoprotein B on clinical outcomes in metabolic syndrome patients with acute myocardial infarction undergoing percutaneous coronary intervention. Korean Circ J. 2012 May;42(5):319-28. doi: 10.4070/kcj.2012.42.5.319. Epub 2012 May 24. PMID: 22701134; PMCID: PMC3369963.
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Korean Circ J. 2012 May;42(5):319-28. doi: 10.4070/kcj.2012.42.5.319. Epub 2012 May 24.

Clinical impact of non-high density lipoprotein-cholesterol and apolipoprotein B on clinical outcomes in metabolic syndrome patients with acute myocardial infarction undergoing percutaneous coronary intervention.

Korean circulation journal

Khurshid Ahmed, Myung Ho Jeong, Rabin Chakraborty, Young Joon Hong, Mi Sook Oh, Kyung Hoon Cho, Min Chol Kim, Daisuke Hachinohe, Seung Hwan Hwang, Min Goo Lee, Doo Sun Sim, Keun Ho Park, Ju Han Kim, Youngkeun Ahn, Jung Chaee Kang

Affiliations

  1. The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea.

PMID: 22701134 PMCID: PMC3369963 DOI: 10.4070/kcj.2012.42.5.319

Abstract

BACKGROUND AND OBJECTIVES: Non-high density lipoprotein-cholesterol (non-HDL-C) and apolipoprotein B (ApoB) are markers of atherosclerotic risk and predictors of cardiovascular events. The aim of this study was to evaluate clinical impact of non-HDL-C and ApoB on clinical outcomes in metabolic syndrome (MS) patients with acute myocardial infarction (AMI) undergoing percuatneous coronary intervetion.

SUBJECTS AND METHODS: We analyzed 470 MS patients (64.4±12.0 years, 53.6% male) with AMI who were followed-up for 12-month after percutaneous coronary intervention (PCI) from December 2005 to January 2008 in a single center. These patients were divided into 2 groups based on median values of non-HDL-C and ApoB. We studied their baseline and follow-up relation with 12-month clinical outcomes, all-cause death and major adverse cardiac events (MACE).

RESULTS: Mean values of baseline non-HDL-C and ApoB were 141.2±43.1 mg/dL and 99.3±29.0 mg/dL respectively. During 12-month follow-up 32 MACE (6.8%) and 12 deaths (2.5%) occurred. We observed significant correlation between non-HDL-C and ApoB. Twelve-month MACE and all-cause death after PCI showed no significant relation as non-HDL-C or ApoB levels increased. Follow-up patients (n=306, rate 65%) also did not show significant relation with clinical outcomes. Twelve-month MACE decreased as non-HDL-C and ApoB reduction rates increased.

CONCLUSION: There was no significant association between higher non-HDL-C or ApoB and 12-month clinical outcomes in MS patients with AMI undergoing PCI. ApoB was found to be a better predictor of 12-month MACE than non-HDL-C based on their reduction rates.

Keywords: Apolipoproteins B; Cholesterol; Metabolic syndrome; Myocardial infarction

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