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Zhanel GG, Hoban DJ, Harding GK. Subinhibitory antimicrobial concentrations: A review of in vitro and in vivo data. Can J Infect Dis. 1992;3(4):193-201doi: 10.1155/1992/793607.
Zhanel, G. G., Hoban, D. J., & Harding, G. K. (1992). Subinhibitory antimicrobial concentrations: A review of in vitro and in vivo data. The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 3(4), 193-201. https://doi.org/10.1155/1992/793607
Zhanel, G G, et al. "Subinhibitory antimicrobial concentrations: A review of in vitro and in vivo data." The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses vol. 3,4 (1992): 193-201. doi: https://doi.org/10.1155/1992/793607
Zhanel GG, Hoban DJ, Harding GK. Subinhibitory antimicrobial concentrations: A review of in vitro and in vivo data. Can J Infect Dis. 1992 Jul;3(4):193-201. doi: 10.1155/1992/793607. PMID: 22514370; PMCID: PMC3328040.
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Can J Infect Dis. 1992 Jul;3(4):193-201. doi: 10.1155/1992/793607.

Subinhibitory antimicrobial concentrations: A review of in vitro and in vivo data.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses

G G Zhanel, D J Hoban, G K Harding

Affiliations

  1. Department of Medical Microbiology, Faculty of Medicine and Faculty of Pharmacy, University of Manitoba; Health Sciences Centre, St Boniface General Hospital and St Boniface General Hospital Research Centre, Winnipeg, Manitoba.

PMID: 22514370 PMCID: PMC3328040 DOI: 10.1155/1992/793607

Abstract

Antimicrobial activity is not an 'all or none' effect. An increase in the rate and extent of antimicrobial action is usually observed over a wide range of antimicrobial concentrations. Subinhibitory antimicrobial concentrations are well known to produce significant antibacterial effects, and various antimicrobials at subinhibitory concentrations have been reported to inhibit the rate of bacterial growth. Bacterial virulence may be increased or decreased by subinhibitory antimicrobial concentrations by changes in the ability of bacteria to adhere to epithelial cells or by alterations in bacterial susceptibility to host immune defences. Animal studies performed in rats, hamsters and rabbits demonstrate decreased bacterial adherence, reduced infectivity and increased survival of animals treated with subinhibitory antimicrobial concentrations compared to untreated controls. The major future role of investigation of subinhibitory antimicrobial concentrations will be to define more fully, at a molecular level, how antimicrobials exert their antibacterial effects.

Keywords: Antimicrobial; Subinhibitory concentrations

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