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Kain KC. Chemotherapy of drug-resistant malaria. Can J Infect Dis. 1996;7(1):25-33doi: 10.1155/1996/139612.
Kain, K. C. (1996). Chemotherapy of drug-resistant malaria. The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 7(1), 25-33. https://doi.org/10.1155/1996/139612
Kain, K C. "Chemotherapy of drug-resistant malaria." The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses vol. 7,1 (1996): 25-33. doi: https://doi.org/10.1155/1996/139612
Kain KC. Chemotherapy of drug-resistant malaria. Can J Infect Dis. 1996 Jan;7(1):25-33. doi: 10.1155/1996/139612. PMID: 22514413; PMCID: PMC3327376.
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Can J Infect Dis. 1996 Jan;7(1):25-33. doi: 10.1155/1996/139612.

Chemotherapy of drug-resistant malaria.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses

K C Kain

Affiliations

  1. Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto and The Toronto Hospital, Toronto, Ontario.

PMID: 22514413 PMCID: PMC3327376 DOI: 10.1155/1996/139612

Abstract

OBJECTIVE: To review the impact of drug-resistant malaria on current management of plasmodial infections.

DATA SOURCES: A MEDLINE search of the English-language medical literature from 1985 to 1995; bibliographies of selected papers; international malaria advisory experts.

DATA SYNTHESIS: Combinations of artemisinin derivatives and mefloquine or atovaquone plus proguanil appear to be the most active drug regimens against multidrug-resistant falciparum malaria from Southeast Asia. The optimal therapy for chloroquine-resistant Plasmodium vivax is unknown, but recent data indicate that halofantrine or chloroquine plus high doses of primaquine are efficacious.

CONCLUSIONS: The incidence of drug-resistant malaria continues to increase at a rate that exceeds new drug development. Ultimately the control of malaria will require more creative approaches than just the development of additional inhibitory drugs. These might include the identification of biochemical pathways unique to the parasite (such as drug efflux and heme polymerization), making it possible to design new classes of antimalarial agents that are selectively toxic to the parasite; methods to block parasite development in the mosquito vector; and multistage vaccines against asexual and sexual stages to block both the pathophysiology and the transmission of disease.

Keywords: Drug-resistant malaria; Plasmodium falciparum; Plasmodium vivax

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