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Reulecke S, Schulz S, Voss A. Autonomic Regulation during Quiet and Active Sleep States in Very Preterm Neonates. Front Physiol. 2012;3:61doi: 10.3389/fphys.2012.00061.
Reulecke, S., Schulz, S., & Voss, A. (2012). Autonomic Regulation during Quiet and Active Sleep States in Very Preterm Neonates. Frontiers in physiology, 361. https://doi.org/10.3389/fphys.2012.00061
Reulecke, Sina, et al. "Autonomic Regulation during Quiet and Active Sleep States in Very Preterm Neonates." Frontiers in physiology vol. 3 (2012): 61. doi: https://doi.org/10.3389/fphys.2012.00061
Reulecke S, Schulz S, Voss A. Autonomic Regulation during Quiet and Active Sleep States in Very Preterm Neonates. Front Physiol. 2012 Apr 10;3:61. doi: 10.3389/fphys.2012.00061. eCollection 2012. PMID: 22514535; PMCID: PMC3322524.
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Front Physiol. 2012 Apr 10;3:61. doi: 10.3389/fphys.2012.00061. eCollection 2012.

Autonomic Regulation during Quiet and Active Sleep States in Very Preterm Neonates.

Frontiers in physiology

Sina Reulecke, Steffen Schulz, Andreas Voss

Affiliations

  1. Department of Medical Engineering and Biotechnology, University of Applied Sciences Jena, Germany.

PMID: 22514535 PMCID: PMC3322524 DOI: 10.3389/fphys.2012.00061

Abstract

The immature autonomic nervous system (ANS) in premature infants regulates heart rate (HR) and respiration different during quiet sleep (QS) and active sleep (AS). Little information is available about ANS regulation in these subjects. The aim of this study was to investigate changes in autonomic regulation and cardiorespiratory coupling during AS and QS in five very preterm neonates with gestational age (GA) 26-31 weeks, applying univariate and bivariate linear and non-linear dynamics methods to the recorded cardiorespiratory signals. During QS univariate linear indices revealed lower standard deviations and entropies, indicating decreased heart rate (HR) variability. More balanced sympatho-vagal behavior of the ANS was revealed by decreased low frequency (LF), increased high frequency (HF), and a trend toward lower ratio LF/HF in QS. Applied non-linear indices (probabilities, entropies, and fractal measures) quantifying the complexity and scaling behavior of HR regulation processes were significantly altered in QS in comparison to AS. This reflects a lower short-term variability, less complexity, and a loss of fractal-like correlation properties of HR dynamics in QS. One major finding is that cardiorespiratory coupling is not yet completely developed in very preterm neonates with 26-31 weeks GA. Significantly different regulation patterns in bivariate oscillations of HR and respiration during AS and QS could be recognized. These patterns were characterized on the one hand by predominant monotonous regulating sequences originating from respiration independently from HR time series in AS, and to a minor degree in QS, and on the other hand by some prominent HR regulation sequences in QS independent of respiratory regulation. We speculate that these findings might be suitable for monitoring preterm neonates and for detecting disorders in the developing cardiorespiratory system.

Keywords: autonomic regulation; cardiorespiratory coupling; non-linear dynamics; preterm newborns; sleep states

References

  1. Electroencephalogr Clin Neurophysiol. 1997 Nov;103(5):528-34 - PubMed
  2. Methods Inf Med. 2004;43(2):202-6 - PubMed
  3. Early Hum Dev. 2009 Oct;85(10):665-71 - PubMed
  4. J Physiol. 2005 Oct 1;568(Pt 1):333-41 - PubMed
  5. Infant Child Dev. 2011 Feb;20(1):106-118 - PubMed
  6. Early Hum Dev. 2005 Apr;81(4):341-50 - PubMed
  7. J Theor Biol. 1985 Apr 21;113(4):759-80 - PubMed
  8. Philos Trans A Math Phys Eng Sci. 2009 Jan 28;367(1887):277-96 - PubMed
  9. IEEE Trans Biomed Eng. 1998 May;45(5):545-52 - PubMed
  10. Chaos. 1995;5(1):82-7 - PubMed
  11. Biomed Tech (Berl). 2006 Oct;51(4):163-6 - PubMed
  12. Early Hum Dev. 1993 Jan;31(3):217-28 - PubMed
  13. Med Biol Eng Comput. 2002 Mar;40(2):241-5 - PubMed
  14. Physiol Meas. 2009 Aug;30(8):847-60 - PubMed
  15. Biol Res Nurs. 2010 Jan;11(3):261-8 - PubMed
  16. Aust N Z J Med. 1995 Feb;25(1):18-26 - PubMed
  17. Circulation. 1997 Mar 18;95(6):1441-8 - PubMed
  18. Am J Cardiol. 2002 Aug 1;90(3):346 - PubMed
  19. Biomed Eng Online. 2011 Oct 03;10:88 - PubMed
  20. Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2695-8 - PubMed
  21. Respir Physiol Neurobiol. 2010 Nov 30;174(1-2):128-34 - PubMed
  22. IEEE Trans Biomed Eng. 2008 Jan;55(1):108-18 - PubMed
  23. Ann Biomed Eng. 2010 Aug;38(8):2542-52 - PubMed
  24. Comput Cardiol. 2008 Sep;35:57-60 - PubMed
  25. Eur Heart J. 1996 Mar;17(3):354-81 - PubMed
  26. Respir Physiol Neurobiol. 2011 Feb 15;175(2):234-8 - PubMed
  27. Early Hum Dev. 2011 Jul;87(7):477-87 - PubMed
  28. Physiol Meas. 2010 Mar;31(3):303-21 - PubMed
  29. Biol Cybern. 1999 Aug;81(2):119-29 - PubMed
  30. J Perinat Med. 2006;34(4):303-8 - PubMed
  31. Early Hum Dev. 2007 Apr;83(4):269-77 - PubMed
  32. Cardiovasc Res. 1996 Mar;31(3):419-33 - PubMed
  33. Am J Physiol Regul Integr Comp Physiol. 2003 Dec;285(6):R1395-401 - PubMed

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