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Mihalef V, Ionasec RI, Sharma P, et al. Patient-specific modelling of whole heart anatomy, dynamics and haemodynamics from four-dimensional cardiac CT images. Interface Focus. 2011;1(3):286-96doi: 10.1098/rsfs.2010.0036.
Mihalef, V., Ionasec, R. I., Sharma, P., Georgescu, B., Voigt, I., Suehling, M., & Comaniciu, D. (2011). Patient-specific modelling of whole heart anatomy, dynamics and haemodynamics from four-dimensional cardiac CT images. Interface focus, 1(3), 286-96. https://doi.org/10.1098/rsfs.2010.0036
Mihalef, Viorel, et al. "Patient-specific modelling of whole heart anatomy, dynamics and haemodynamics from four-dimensional cardiac CT images." Interface focus vol. 1,3 (2011): 286-96. doi: https://doi.org/10.1098/rsfs.2010.0036
Mihalef V, Ionasec RI, Sharma P, Georgescu B, Voigt I, Suehling M, Comaniciu D. Patient-specific modelling of whole heart anatomy, dynamics and haemodynamics from four-dimensional cardiac CT images. Interface Focus. 2011 Jun 06;1(3):286-96. doi: 10.1098/rsfs.2010.0036. Epub 2011 Mar 23. PMID: 22670200; PMCID: PMC3262442.
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Interface Focus. 2011 Jun 06;1(3):286-96. doi: 10.1098/rsfs.2010.0036. Epub 2011 Mar 23.

Patient-specific modelling of whole heart anatomy, dynamics and haemodynamics from four-dimensional cardiac CT images.

Interface focus

Viorel Mihalef, Razvan Ioan Ionasec, Puneet Sharma, Bogdan Georgescu, Ingmar Voigt, Michael Suehling, Dorin Comaniciu

Affiliations

  1. Image Analytics and Informatics, Siemens Corporate Research, Princeton, NJ , USA.

PMID: 22670200 PMCID: PMC3262442 DOI: 10.1098/rsfs.2010.0036

Abstract

There is a growing need for patient-specific and holistic modelling of the heart to support comprehensive disease assessment and intervention planning as well as prediction of therapeutic outcomes. We propose a patient-specific model of the whole human heart, which integrates morphology, dynamics and haemodynamic parameters at the organ level. The modelled cardiac structures are robustly estimated from four-dimensional cardiac computed tomography (CT), including all four chambers and valves as well as the ascending aorta and pulmonary artery. The patient-specific geometry serves as an input to a three-dimensional Navier-Stokes solver that derives realistic haemodynamics, constrained by the local anatomy, along the entire heart cycle. We evaluated our framework with various heart pathologies and the results correlate with relevant literature reports.

Keywords: CT; cardiac; computational fluid dynamics; haemodynamics; level sets; whole heart

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