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Marwaha AK, Leung NJ, McMurchy AN, et al. TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?. Front Immunol. 2012;3:129doi: 10.3389/fimmu.2012.00129.
Marwaha, A. K., Leung, N. J., McMurchy, A. N., & Levings, M. K. (2012). TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?. Frontiers in immunology, 3129. https://doi.org/10.3389/fimmu.2012.00129
Marwaha, Ashish K, et al. "TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?." Frontiers in immunology vol. 3 (2012): 129. doi: https://doi.org/10.3389/fimmu.2012.00129
Marwaha AK, Leung NJ, McMurchy AN, Levings MK. TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?. Front Immunol. 2012 Jun 04;3:129. doi: 10.3389/fimmu.2012.00129. eCollection 2012. PMID: 22675324; PMCID: PMC3366440.
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Front Immunol. 2012 Jun 04;3:129. doi: 10.3389/fimmu.2012.00129. eCollection 2012.

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?.

Frontiers in immunology

Ashish K Marwaha, Nicole J Leung, Alicia N McMurchy, Megan K Levings

Affiliations

  1. Department of Pathology and Laboratory Medicine, University of British Columbia Vancouver, BC, Canada.

PMID: 22675324 PMCID: PMC3366440 DOI: 10.3389/fimmu.2012.00129

Abstract

In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the center of attention in immunology. Initial studies painted Th17 cells as the culprit for destruction in many different autoimmune and auto-inflammatory diseases. Subsequently, the discovery of patients with primary immunodeficiencies in the IL-17 pathway taught us that Th17 cells have a critical role in defense against certain fungal and bacterial infections. Moreover, the paradoxical exacerbation of Crohn's disease in the clinical trials of a Secukinumab (AIN457), a fully human neutralizing antibody to IL-17A, has cast into doubt a universal pro-inflammatory and harmful role for Th17 cells. Evidence now suggests that depending on the environment Th17 cells can alter their differentiation program, ultimately giving rise to either protective or pro-inflammatory cells. In this review we will summarize the evidence from patients with immunodeficiencies, autoimmune, or auto-inflammatory diseases that teaches us how the pro-inflammatory versus protective function of Th17 cells varies within the context of different human diseases.

Keywords: T regulatory cells; Th17 cells; autoimmunity; immunodeficiency; inflammatory bowel disease; psoriasis; secukinumab; type 1 diabetes

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