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Alemany M. Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?. Front Endocrinol (Lausanne). 2012;3:27doi: 10.3389/fendo.2012.00027.
Alemany, M. (2012). Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?. Frontiers in endocrinology, 327. https://doi.org/10.3389/fendo.2012.00027
Alemany, Marià. "Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?." Frontiers in endocrinology vol. 3 (2012): 27. doi: https://doi.org/10.3389/fendo.2012.00027
Alemany M. Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?. Front Endocrinol (Lausanne). 2012 Feb 27;3:27. doi: 10.3389/fendo.2012.00027. eCollection 2012. PMID: 22649414; PMCID: PMC3355885.
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Front Endocrinol (Lausanne). 2012 Feb 27;3:27. doi: 10.3389/fendo.2012.00027. eCollection 2012.

Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?.

Frontiers in endocrinology

Marià Alemany

Affiliations

  1. Faculty of Biology, Department of Nutrition and Food Science, University of Barcelona Barcelona, Spain. [email protected]

PMID: 22649414 PMCID: PMC3355885 DOI: 10.3389/fendo.2012.00027

Abstract

The metabolic syndrome is basically a maturity-onset disease. Typically, its manifestations begin to flourish years after the initial dietary or environmental aggression began. Since most hormonal, metabolic, or defense responses are practically immediate, the procrastinated response do not seem justified. Only in childhood, the damages of the metabolic syndrome appear with minimal delay. Sex affects the incidence of the metabolic syndrome, but this is more an effect of timing than absolute gender differences, females holding better than males up to menopause, when the differences between sexes tend to disappear. The metabolic syndrome is related to an immune response, countered by a permanent increase in glucocorticoids, which keep the immune system at bay but also induce insulin resistance, alter the lipid metabolism, favor fat deposition, mobilize protein, and decrease androgen synthesis. Androgens limit the operation of glucocorticoids, which is also partly blocked by estrogens, since they decrease inflammation (which enhances glucocorticoid release). These facts suggest that the appearance of the metabolic syndrome symptoms depends on the strength (i.e., levels) of androgens and estrogens. The predominance of glucocorticoids and the full manifestation of the syndrome in men are favored by decreased androgen activity. Low androgens can be found in infancy, maturity, advanced age, or because of their inhibition by glucocorticoids (inflammation, stress, medical treatment). Estrogens decrease inflammation and reduce the glucocorticoid response. Low estrogen (infancy, menopause) again allow the predominance of glucocorticoids and the manifestation of the metabolic syndrome. It is postulated that the equilibrium between sex hormones and glucocorticoids may be a critical element in the timing of the manifestation of metabolic syndrome-related pathologies.

Keywords: androgens; estrogens; glucocorticoids; metabolic syndrome; obesity

References

  1. Metabolism. 1991 Feb;40(2):187-90 - PubMed
  2. Pediatr Int. 2002 Apr;44(2):149-52 - PubMed
  3. Proc Nutr Soc. 2000 Nov;59(4):573-9 - PubMed
  4. QJM. 2006 May;99(5):317-25 - PubMed
  5. Int J Pediatr Obes. 2011 Oct;6(5-6):361-88 - PubMed
  6. N Engl J Med. 1988 Feb 25;318(8):467-72 - PubMed
  7. Diabet Med. 2003 May;20(5):406-15 - PubMed
  8. J Clin Invest. 2011 Jun;121(6):2087-93 - PubMed
  9. BJOG. 2006 Oct;113(10):1141-7 - PubMed
  10. N Engl J Med. 1986 Dec 11;315(24):1519-24 - PubMed
  11. J Steroid Biochem Mol Biol. 1991 May;38(5):599-609 - PubMed
  12. Exp Clin Endocrinol Diabetes. 2005 Oct;113(9):522-8 - PubMed
  13. APMIS. 2001 Jan;109(1):1-8 - PubMed
  14. Obes Rev. 2011 May;12(5):e54-63 - PubMed
  15. Hepatology. 2008 Aug;48(2):458-73 - PubMed
  16. Pflugers Arch. 2007 Dec;455(3):479-92 - PubMed
  17. J Steroid Biochem Mol Biol. 2011 Apr;124(3-5):99-111 - PubMed
  18. Front Biosci. 2002 Sep 01;7:d1879-98 - PubMed
  19. Diabetes. 1997 Apr;46(4):717-9 - PubMed
  20. Ann Epidemiol. 2007 Apr;17(4):270 - PubMed
  21. Gynecol Endocrinol. 2004 Aug;19(2):69-78 - PubMed
  22. Endocr Res. 2003 Nov;29(4):411-8 - PubMed
  23. J Appl Physiol (1985). 2010 Jul;109(1):3-10 - PubMed
  24. Biochem Biophys Res Commun. 2005 Oct 14;336(1):3-8 - PubMed
  25. Exp Biol Med (Maywood). 2008 Sep;233(9):1066-80 - PubMed
  26. Blood Purif. 1995;13(3-4):147-52 - PubMed
  27. Diabetes Care. 2008 Feb;31 Suppl 2:S262-8 - PubMed
  28. Obes Rev. 2004 Feb;5(1):21-6 - PubMed
  29. Cytokine. 2003 Jan 21;21(2):91-7 - PubMed
  30. Chronobiol Int. 2007;24(5):969-90 - PubMed
  31. J Leukoc Biol. 2008 Oct;84(4):924-31 - PubMed
  32. Int J Obes Relat Metab Disord. 1996 Jun;20(6):588-94 - PubMed
  33. Public Health Nutr. 2010 Oct;13(10A):1693-700 - PubMed
  34. Horm Res. 1996;45(3-5):202-6 - PubMed
  35. Ann N Y Acad Sci. 1994 Nov 30;746:101-12; discussion 112-4 - PubMed
  36. Physiol Behav. 1976 Sep;17(3):461-71 - PubMed
  37. Obes Res. 2005 Jul;13(7):1157-66 - PubMed
  38. Maturitas. 2006 Jul 20;54(4):335-41 - PubMed
  39. J Appl Physiol (1985). 1989 Jan;66(1):498-503 - PubMed
  40. J Clin Endocrinol Metab. 2011 Jan;96(1):66-8 - PubMed
  41. Am Heart J. 2009 Aug;158(2):257-262.e1 - PubMed
  42. Curr Hypertens Rep. 2011 Apr;13(2):149-57 - PubMed
  43. Nutr Rev. 2002 May;60(5 Pt 1):148-51 - PubMed
  44. Am J Clin Nutr. 1978 Nov;31(11):1975-7 - PubMed
  45. Lancet. 1994 Jun 11;343(8911):1479-81 - PubMed
  46. Obesity (Silver Spring). 2007 Apr;15(4):977-85 - PubMed
  47. J Endocrinol. 1969 Apr;43(4):563-70 - PubMed
  48. Paediatr Respir Rev. 2006 Dec;7(4):247-59 - PubMed
  49. Metabolism. 2006 Nov;55(11):1473-80 - PubMed
  50. J Clin Endocrinol Metab. 2005 May;90(5):2636-41 - PubMed
  51. Mol Cancer Res. 2003 Nov;1(13):981-91 - PubMed
  52. Pediatrics. 2002 Sep;110(3):497-504 - PubMed
  53. J Gerontol A Biol Sci Med Sci. 2010 Jan;65(1):111-7 - PubMed
  54. Am J Physiol. 1982 Jun;242(6):E353-9 - PubMed
  55. Int J Obes Relat Metab Disord. 1999 Jul;23(7):678-85 - PubMed
  56. J Pediatr. 1998 Dec;133(6):745-9 - PubMed
  57. Int J Obes Relat Metab Disord. 2004 Dec;28 Suppl 4:S45-52 - PubMed
  58. Obstet Gynecol. 1996 May;87(5 Pt 2):897-904 - PubMed
  59. J Clin Endocrinol Metab. 2006 Mar;91(3):892-8 - PubMed
  60. Am J Clin Nutr. 2010 Jun;91(6):1560-7 - PubMed
  61. Steroids. 2008 Oct;73(9-10):864-9 - PubMed
  62. Am J Clin Nutr. 1998 Mar;67(3 Suppl):546S-550S - PubMed
  63. J Endocrinol. 1992 Mar;132(3):425-31 - PubMed
  64. Mol Cell Biochem. 2004 May;260(1-2):91-102 - PubMed
  65. J Clin Endocrinol Metab. 2003 Mar;88(3):1389-93 - PubMed
  66. Curr Opin Lipidol. 1999 Feb;10(1):47-52 - PubMed
  67. J Androl. 2004 Nov-Dec;25(6):973-81 - PubMed
  68. Eur J Clin Invest. 2002 May;32(5):345-53 - PubMed
  69. Diabetes Care. 2003 Oct;26(10):2954-6 - PubMed
  70. Int J Obes (Lond). 2008 Dec;32 Suppl 7:S62-71 - PubMed
  71. Am J Physiol. 1995 Nov;269(5 Pt 1):E820-6 - PubMed
  72. Endocrinology. 2000 Feb;141(2):560-3 - PubMed
  73. Diabetes. 1996 Jul;45(7):984-7 - PubMed
  74. J Steroid Biochem Mol Biol. 1990 Nov 20;37(3):395-403 - PubMed
  75. Clin Sci (Lond). 2002 Feb;102(2):151-66 - PubMed
  76. Pharmacol Biochem Behav. 2010 Nov;97(1):121-9 - PubMed
  77. Mol Cell Endocrinol. 2010 Jan 15;314(1):1-16 - PubMed
  78. Acta Endocrinol (Copenh). 1986 Jul;112(3):442-6 - PubMed
  79. J Clin Oncol. 2000 Nov 1;18(21):3668-76 - PubMed
  80. Biochem Biophys Res Commun. 1998 Jul 30;248(3):443-9 - PubMed
  81. J Mol Endocrinol. 2000 Oct;25(2):149-56 - PubMed
  82. Aging Male. 2006 Jun;9(2):75-9 - PubMed
  83. J Nutr. 2009 Feb;139(2):412S-6S - PubMed
  84. J Endocrinol. 2008 Jul;198(1):127-34 - PubMed
  85. Diabetes. 2005 Dec;54 Suppl 2:S108-13 - PubMed
  86. J Physiol Pharmacol. 2009 Mar;60(1):181-90 - PubMed
  87. Diabetes Care. 2008 Dec;31(12):2380-2 - PubMed
  88. Steroids. 2003 Aug;68(6):543-50 - PubMed
  89. Diabetes. 1987 Mar;36(3):327-34 - PubMed
  90. Int J Obes Relat Metab Disord. 2003 Sep;27(9):1100-5 - PubMed
  91. BMJ. 2010 Jun 15;340:c2826 - PubMed
  92. Steroids. 2010 Jan;75(1):20-6 - PubMed
  93. Endocrinology. 2008 Sep;149(9):4267-8 - PubMed
  94. Int J Androl. 2002 Oct;25(5):312-6 - PubMed
  95. Eur J Nutr. 2001 Feb;40(1):17-22 - PubMed
  96. J Exp Med. 1959 Feb 1;109(2):173-86 - PubMed
  97. Eur J Hum Genet. 2007 Jul;15(7):784-90 - PubMed
  98. Ann Epidemiol. 2011 Feb;21(2):103-10 - PubMed
  99. Int J Obes Relat Metab Disord. 2004 Apr;28(4):494-9 - PubMed
  100. J Environ Qual. 2006 Jan 03;35(1):122-32 - PubMed
  101. Am J Clin Nutr. 2000 Sep;72(3):690-3 - PubMed
  102. J Immunol. 2005 Nov 15;175(10):6509-16 - PubMed
  103. Diabetes. 2009 Sep;58(9):2027-31 - PubMed
  104. Int J Obes (Lond). 2008 Dec;32 Suppl 6:S11-8 - PubMed
  105. Diabetes Care. 2010 Jul;33(7):1618-24 - PubMed
  106. Toxicol Sci. 2004 Jul;80(1):14-25 - PubMed
  107. Diabetologia. 2005 Oct;48(10):2119-30 - PubMed
  108. Am J Obstet Gynecol. 2008 Jun;198(6):670.e1-7; discussion 670.e7-10 - PubMed
  109. Planta Med. 2008 Jan;74(1):25-32 - PubMed
  110. Mol Endocrinol. 2008 Jul;22(7):1565-78 - PubMed
  111. Horm Metab Res. 1996 Dec;28(12):744-7 - PubMed
  112. Horm Res. 1996;45(1-2):74-80 - PubMed
  113. Nat Med. 2002 May;8(5):473-9 - PubMed
  114. Eur J Endocrinol. 2006 Jun;154(6):899-906 - PubMed
  115. J Gastroenterol. 2011 Jan;46 Suppl 1:70-8 - PubMed
  116. Int J Obes Relat Metab Disord. 1999 Apr;23(4):366-73 - PubMed
  117. Cardiovasc Res. 2011 Jan 1;89(1):119-28 - PubMed
  118. Diabetologia. 2010 Nov;53(11):2417-30 - PubMed
  119. Postgrad Med J. 2009 Nov;85(1009):614-21 - PubMed
  120. Reprod Biol Endocrinol. 2011 Jul 28;9:101 - PubMed
  121. J Cell Biochem. 2007 Apr 15;100(6):1352-69 - PubMed
  122. Int J Gynaecol Obstet. 2008 Mar;100(3):280-1 - PubMed
  123. Am Heart J. 2005 Jan;149(1):33-45 - PubMed
  124. Clin Hemorheol Microcirc. 1999;21(3-4):169-77 - PubMed
  125. Diabetes Metab. 2005 Feb;31(1):55-62 - PubMed
  126. Arch Intern Med. 2008 Jul 28;168(14):1568-75 - PubMed
  127. J Physiol. 2005 Sep 15;567(Pt 3):951-61 - PubMed
  128. FEBS J. 2006 Apr;273(7):1362-72 - PubMed
  129. Nat Genet. 1996 May;13(1):18-9 - PubMed
  130. Nutr Metab Cardiovasc Dis. 2008 Mar;18(3):242-51 - PubMed
  131. Regul Pept. 2007 Mar 1;139(1-3):45-51 - PubMed
  132. J Agric Food Chem. 2006 Dec 27;54(26):9785-91 - PubMed
  133. Fertil Steril. 2010 Nov;94(6):2197-201 - PubMed
  134. Obes Rev. 2004 Aug;5(3):167-70 - PubMed
  135. Biochem J. 1979 Jan 15;178(1):139-46 - PubMed
  136. Horm Metab Res. 2001 Jul;33(7):407-11 - PubMed
  137. Clin Obstet Gynecol. 2004 Dec;47(4):957-66; discussion 980-1 - PubMed
  138. Trends Endocrinol Metab. 2011 Jan;22(1):24-33 - PubMed
  139. J Clin Endocrinol Metab. 2002 Jan;87(1):166-75 - PubMed
  140. Endocr Rev. 2007 Aug;28(5):521-74 - PubMed
  141. Obesity (Silver Spring). 2009 Aug;17(8):1596-602 - PubMed
  142. Asian J Androl. 2008 Jan;10(1):134-45 - PubMed
  143. Obes Rev. 2004 May;5(2):115-21 - PubMed
  144. Int J Obes. 1982;6(6):513-25 - PubMed
  145. Int J Clin Pract. 2007 Feb;61(2):341-4 - PubMed
  146. Arch Biochem Biophys. 1996 Dec 15;336(2):224-30 - PubMed
  147. Mol Cell Endocrinol. 2001 Jan 22;171(1-2):1-4 - PubMed
  148. J Androl. 2009 Jan-Feb;30(1):23-32 - PubMed
  149. Metabolism. 2005 Aug;54(8):1034-40 - PubMed
  150. Nutr J. 2009 Feb 17;8:11 - PubMed
  151. Steroids. 2007 Jun;72(6-7):600-8 - PubMed
  152. Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):369-75 - PubMed
  153. Endocrinology. 2001 Mar;142(3):1202-8 - PubMed
  154. Am J Hum Genet. 1998 Sep;63(3):831-8 - PubMed
  155. Int J Obes (Lond). 2011 Jan;35(1):1-15 - PubMed
  156. Nutrition. 2000 Oct;16(10):924-36 - PubMed
  157. Nature. 1994 Dec 1;372(6505):425-32 - PubMed
  158. J Clin Endocrinol Metab. 2006 Feb;91(2):492-7 - PubMed
  159. Obes Res. 2005 Sep;13(9):1485-90 - PubMed
  160. J Clin Endocrinol Metab. 1994 Jun;78(6):1331-5 - PubMed
  161. Metabolism. 2008 Nov;57(11):1539-44 - PubMed
  162. Eur J Endocrinol. 2004 Jul;151(1):1-14 - PubMed
  163. J Law Med Ethics. 2007 Spring;35(1):35-60 - PubMed
  164. BMC Public Health. 2010 Sep 01;10:525 - PubMed
  165. Metab Syndr Relat Disord. 2006 Summer;4(2):129-37 - PubMed
  166. Gend Med. 2007;4 Suppl B:S162-77 - PubMed
  167. Mol Cell Endocrinol. 1981 Feb;21(2):97-108 - PubMed
  168. J Adolesc Health. 2011 Mar;48(3):275-80 - PubMed
  169. Obes Surg. 2008 Oct;18(10):1273-7 - PubMed
  170. Steroids. 1997 Jan;62(1):148-58 - PubMed
  171. Ann N Y Acad Sci. 2006 Nov;1089:302-23 - PubMed
  172. Steroids. 2006 Sep;71(9):799-808 - PubMed
  173. J Lipid Res. 2011 Sep;52(9):1626-35 - PubMed
  174. Compr Ther. 2003 Summer-Fall;29(2-3):157-65 - PubMed
  175. Neuroreport. 2001 Jul 3;12(9):1965-70 - PubMed
  176. Asian J Androl. 2010 Jul;12(4):535-47 - PubMed
  177. J Physiol. 2009 Nov 1;587(Pt 21):5019-23 - PubMed
  178. Metabolism. 2006 Oct;55(10):1352-7 - PubMed
  179. Diabetes Care. 2007 Apr;30(4):974-9 - PubMed
  180. Steroids. 2005 Aug;70(9):667-72 - PubMed
  181. Acta Obstet Gynecol Scand. 2006;85(9):1090-3 - PubMed
  182. Pharmacol Ther. 2010 May;126(2):159-72 - PubMed
  183. Med Sci Sports Exerc. 2010 Nov;42(11):1973-80 - PubMed
  184. Mol Cell Biochem. 1994 Feb 23;131(2):99-104 - PubMed
  185. Int J Obes. 1990;14 Suppl 3:1-10 - PubMed
  186. J Adolesc Health. 2009 Oct;45(4):344-50 - PubMed
  187. Am J Clin Nutr. 2008 Feb;87(2):398-404 - PubMed
  188. Ann N Y Acad Sci. 2004 Jun;1024:124-37 - PubMed
  189. J Clin Invest. 2006 Jul;116(7):1802-12 - PubMed
  190. Ann Med. 2000 Apr;32(3):181-6 - PubMed
  191. Endocrine. 2006 Apr;29(2):209-15 - PubMed
  192. Diabetes. 2010 Jan;59(1):71-9 - PubMed
  193. Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S7-12 - PubMed
  194. Clin Biochem. 2003 Sep;36(6):413-20 - PubMed
  195. Fertil Steril. 2002 Dec;78(6):1187-94 - PubMed
  196. Endocrinology. 2007 Aug;148(8):4056-63 - PubMed
  197. Ann Med. 1991 Oct;23(4):447-52 - PubMed
  198. Hypertens Res. 2010 Jun;33(6):587-91 - PubMed
  199. Hepatology. 2008 Aug;48(2):474-86 - PubMed
  200. PLoS Comput Biol. 2009 Mar;5(3):e1000324 - PubMed
  201. Am J Med Genet A. 2008 Mar 1;146A(5):665-9 - PubMed
  202. Biochem J. 1975 Aug;150(2):235-43 - PubMed
  203. Diabetes Care. 2004 Oct;27(10):2438-43 - PubMed
  204. Physiol Behav. 2005 Dec 15;86(5):614-22 - PubMed
  205. Hum Reprod Update. 2009 Jan-Feb;15(1):119-38 - PubMed
  206. Ann N Y Acad Sci. 1995 Dec 29;771:665-76 - PubMed
  207. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E313-22 - PubMed
  208. Phytother Res. 2003 Sep;17(8):845-69 - PubMed
  209. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13410-5 - PubMed
  210. J Am Diet Assoc. 2008 Apr;108(4 Suppl 1):S24-8 - PubMed
  211. Biophys J. 2004 Aug;87(2):768-79 - PubMed
  212. Eur J Nutr. 1999 Oct;38(5):247-53 - PubMed
  213. Clin Endocrinol (Oxf). 2011 Jan;74(1):30-6 - PubMed
  214. J Clin Endocrinol Metab. 1985 Jan;60(1):174-7 - PubMed
  215. Nature. 1984 Feb 23-29;307(5953):747-9 - PubMed
  216. J Intern Med. 2003 Nov;254(5):401-25 - PubMed
  217. Int J Obes (Lond). 2006 Dec;30 Suppl 4:S50-7 - PubMed
  218. Best Pract Res Clin Endocrinol Metab. 2005 Sep;19(3):327-41 - PubMed
  219. Eur J Pharmacol. 2008 May 13;585(2-3):483-91 - PubMed
  220. Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R91-6 - PubMed
  221. Int J Cardiol. 2004 Aug;96(2):223-7 - PubMed
  222. Stress. 2011 May;14(3):233-46 - PubMed
  223. Eur J Endocrinol. 2009 Oct;161(4):591-8 - PubMed
  224. Obes Rev. 2009 May;10(3):342-9 - PubMed
  225. Am J Physiol. 1990 May;258(5 Pt 1):E888-93 - PubMed
  226. Coron Artery Dis. 1998;9(8):483-7 - PubMed
  227. Am J Physiol. 1987 Mar;252(3 Pt 1):E396-407 - PubMed
  228. BMC Pediatr. 2003 Apr 30;3:3 - PubMed
  229. Am J Med Sci. 2009 Oct;338(4):310-8 - PubMed
  230. Biochim Biophys Acta. 2010 Mar;1801(3):338-49 - PubMed
  231. J Endocrinol. 2007 Mar;192(3):585-94 - PubMed
  232. Hum Reprod. 1997 Oct;12 Suppl 1:53-62 - PubMed
  233. J Mol Biol. 1972 Jun 14;67(1):99-115 - PubMed
  234. J Clin Endocrinol Metab. 2008 May;93(5):1834-40 - PubMed
  235. Med Hypotheses. 2004;62(1):133-42 - PubMed
  236. Endocrinology. 2004 Jan;145(1):11-2 - PubMed
  237. J Med Genet. 1997 Nov;34(11):917-23 - PubMed
  238. Domest Anim Endocrinol. 2004 Apr;26(3):201-14 - PubMed
  239. Int J Impot Res. 2008 Jul-Aug;20(4):358-65 - PubMed
  240. Acta Paediatr. 2006 Aug;95(8):1005-11 - PubMed
  241. J Clin Invest. 1979 Jul;64(1):145-54 - PubMed
  242. Gynecol Endocrinol. 2007 Jan;23(1):25-8 - PubMed

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