Display options
Cite
Davydova AS, Vorobjeva MA, Venyaminova AG. Escort aptamers: new tools for the targeted delivery of therapeutics into cells. Acta Naturae. 2011;3(4):12-29
Davydova, A. S., Vorobjeva, M. A., & Venyaminova, A. G. (2011). Escort aptamers: new tools for the targeted delivery of therapeutics into cells. Acta naturae, 3(4), 12-29.
Davydova, A S, et al. "Escort aptamers: new tools for the targeted delivery of therapeutics into cells." Acta naturae vol. 3,4 (2011): 12-29.
Davydova AS, Vorobjeva MA, Venyaminova AG. Escort aptamers: new tools for the targeted delivery of therapeutics into cells. Acta Naturae. 2011 Oct;3(4):12-29. PMID: 22649701; PMCID: PMC3347615.
Copy Download .nbib Format: NLM
Share it on

Acta Naturae. 2011 Oct;3(4):12-29.

Escort aptamers: new tools for the targeted delivery of therapeutics into cells.

Acta naturae

A S Davydova, M A Vorobjeva, A G Venyaminova

Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences.

PMID: 22649701 PMCID: PMC3347615

Abstract

Escort aptamers are DNA or RNA sequences with high affinity to certain cell-surface proteins, which can be used for targeted delivery of various agents into cells of a definite type. The peculiarities of the selection of escort aptamers are discussed in this review. The methods used in selection of escort aptamers via the SELEX technique are considered, including selection against isolated cell-surface proteins, cell fragments, living eukaryotic cells, and bacteria. Particular attention is given to the design and chemical modification of escort aptamers. The different fields of application of escort aptamers are described, including the targeted delivery of siRNAs, nanoparticles, toxins, and photoagents, as well as the identification of specific cell markers and the detection or isolation of cells of a definite type. The potential for the application of escort aptamers in the development of new therapeutic agents and diagnostic systems is also discussed.

Keywords: NA aptamers; SELEX method; addressed cell delivery; detection of cells; escort aptamers; specific cell binding

References

  1. Biomol Eng. 2007 Oct;24(4):381-403 - PubMed
  2. J Biol Chem. 2001 Dec 28;276(52):48644-54 - PubMed
  3. Biosens Bioelectron. 2006 Apr 15;21(10):1859-66 - PubMed
  4. J Clin Invest. 2000 Oct;106(8):923-8 - PubMed
  5. Biomaterials. 2007 Feb;28(5):869-76 - PubMed
  6. Bioconjug Chem. 2008 Jun;19(6):1309-12 - PubMed
  7. Mol Cell Probes. 2009 Feb;23(1):20-8 - PubMed
  8. Cancer Res. 2006 Jun 15;66(12):5989-92 - PubMed
  9. Int J Parasitol. 2003 Oct;33(12):1309-17 - PubMed
  10. J Proteome Res. 2009 May;8(5):2438-48 - PubMed
  11. Anal Chem. 2008 Oct 15;80(20):7812-9 - PubMed
  12. Angew Chem Int Ed Engl. 2009;48(40):7334-7 - PubMed
  13. Antimicrob Agents Chemother. 2005 Oct;49(10):4052-60 - PubMed
  14. Anal Chem. 2007 Jul 1;79(13):4900-7 - PubMed
  15. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15908-13 - PubMed
  16. Nat Biotechnol. 2009 Sep;27(9):839-49 - PubMed
  17. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11838-43 - PubMed
  18. J Proteome Res. 2008 May;7(5):2133-9 - PubMed
  19. Nature. 1990 Mar 29;344(6265):467-8 - PubMed
  20. Acc Chem Res. 2008 Jan;41(1):130-8 - PubMed
  21. Chemistry. 2009;15(21):5327-36 - PubMed
  22. Methods Enzymol. 1996;267:275-301 - PubMed
  23. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6315-20 - PubMed
  24. Comb Chem High Throughput Screen. 2006 Aug;9(7):491-9 - PubMed
  25. Chem Biol. 2005 Jan;12(1):25-33 - PubMed
  26. Angew Chem Int Ed Engl. 2006 Dec 11;45(48):8149-52 - PubMed
  27. Ann Pharmacother. 2006 Jul-Aug;40(7-8):1322-6 - PubMed
  28. Chembiochem. 2009 Mar 23;10(5):862-8 - PubMed
  29. Bioorg Med Chem. 2001 Oct;9(10):2571-80 - PubMed
  30. Biosens Bioelectron. 2009 Jul 15;24(11):3175-82 - PubMed
  31. J Immunol. 1998 Jun 1;160(11):5209-12 - PubMed
  32. Anal Chem. 2009 Dec 15;81(24):10013-8 - PubMed
  33. Nucleic Acids Res. 2009 Feb;37(3):866-76 - PubMed
  34. J Cell Mol Med. 2005 Jul-Sep;9(3):731-6 - PubMed
  35. Oligonucleotides. 2006 Winter;16(4):323-35 - PubMed
  36. Nucleic Acids Res. 2009 Aug;37(14):4621-8 - PubMed
  37. Stem Cells. 2006 Oct;24(10):2220-31 - PubMed
  38. Nucleic Acids Res. 2009 May;37(9):3094-109 - PubMed
  39. Chemistry. 2008;14(6):1769-75 - PubMed
  40. Science. 1990 Aug 3;249(4968):505-10 - PubMed
  41. Langmuir. 2008 Oct 21;24(20):11860-5 - PubMed
  42. Cancer Res. 2003 Nov 1;63(21):7483-9 - PubMed
  43. Angew Chem Int Ed Engl. 2009;48(15):2672-89 - PubMed
  44. J Nucl Med. 2006 Apr;47(4):668-78 - PubMed
  45. J Biomed Mater Res A. 2008 Mar 1;84(3):614-21 - PubMed
  46. Anal Bioanal Chem. 2008 Feb;390(4):1039-50 - PubMed
  47. Leukemia. 2009 Feb;23(2):235-44 - PubMed
  48. J Fluoresc. 2010 Nov;20(6):1211-23 - PubMed
  49. Eukaryot Cell. 2003 Feb;2(1):84-94 - PubMed
  50. Handb Exp Pharmacol. 2006;(173):375-93 - PubMed
  51. Oligonucleotides. 2010 Oct;20(5):215-24 - PubMed
  52. Small. 2008 Feb;4(2):197-201 - PubMed
  53. Methods Mol Biol. 2009;504:385-98 - PubMed
  54. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15416-21 - PubMed
  55. J Biotechnol. 2003 Apr 10;102(1):15-22 - PubMed
  56. Anal Chem. 2008 Feb 1;80(3):567-72 - PubMed
  57. Nature. 1990 Aug 30;346(6287):818-22 - PubMed
  58. J Fluoresc. 2007 Mar;17(2):193-9 - PubMed
  59. Biochimie. 2006 Jul;88(7):897-904 - PubMed
  60. J Am Chem Soc. 2008 Jul 16;130(28):9137-43 - PubMed
  61. Q J Nucl Med Mol Imaging. 2007 Dec;51(4):292-6 - PubMed
  62. Clin Chem. 2007 Jun;53(6):1153-5 - PubMed
  63. Nucleic Acids Res. 2011 Mar;39(6):2458-69 - PubMed
  64. Oligonucleotides. 2011 Feb;21(1):1-10 - PubMed
  65. Nano Lett. 2005 Sep;5(9):1797-808 - PubMed
  66. Chem Commun (Camb). 2010 Aug 14;46(30):5566-8 - PubMed
  67. Appl Microbiol Biotechnol. 2010 Aug;87(6):2323-34 - PubMed
  68. Nat Rev Drug Discov. 2006 Feb;5(2):123-32 - PubMed
  69. Curr Cancer Drug Targets. 2008 Nov;8(7):554-65 - PubMed
  70. Int J Cancer. 2011 Feb 15;128(4):797-804 - PubMed
  71. Curr Opin Chem Biol. 1997 Jun;1(1):26-31 - PubMed
  72. Anal Chem. 2005 Sep 1;77(17):5453-9 - PubMed
  73. Methods Enzymol. 2000;317:65-74 - PubMed
  74. Biosens Bioelectron. 2009 Aug 15;24(12):3550-5 - PubMed
  75. Mol Cell Proteomics. 2007 Dec;6(12):2230-8 - PubMed
  76. J Biol Chem. 2001 May 11;276(19):16464-8 - PubMed
  77. Nat Biotechnol. 2006 Aug;24(8):1005-15 - PubMed
  78. Cancer Res. 2002 Jul 15;62(14):4029-33 - PubMed
  79. Nucleic Acids Res. 1999 May 1;27(9):2006-14 - PubMed
  80. Nat Biotechnol. 2004 Sep;22(9):1155-60 - PubMed
  81. Nat Chem Biol. 2010 Jan;6(1):22-4 - PubMed
  82. Anal Chem. 2008 Feb 1;80(3):721-8 - PubMed
  83. J Biol Chem. 2002 Jun 7;277(23):20756-62 - PubMed
  84. Macromol Biosci. 2009 Sep 9;9(9):831-5 - PubMed
  85. Cancer Res. 2004 Nov 1;64(21):7668-72 - PubMed
  86. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2902-7 - PubMed
  87. Nucleic Acids Res. 1998 Sep 1;26(17):3915-24 - PubMed
  88. Nucleic Acids Res. 2004 Oct 27;32(19):5757-65 - PubMed
  89. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):5-10 - PubMed
  90. Chembiochem. 2007 Apr 16;8(6):603-6 - PubMed
  91. Tumour Biol. 2006;27(6):289-301 - PubMed
  92. ChemMedChem. 2008 Jun;3(6):991-1001 - PubMed
  93. Biochem Biophys Res Commun. 2007 Jun 8;357(3):743-8 - PubMed
  94. Parasitol Res. 2009 Nov;105(6):1557-66 - PubMed

Publication Types