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Case Rep Oncol Med. 2011;2011:517047. doi: 10.1155/2011/517047. Epub 2011 Jul 06.

Primary breast angiosarcoma: avoiding a common trap.

Case reports in oncological medicine

Christine Desbiens, Jean-Charles Hogue, Yves Lévesque

Affiliations

  1. Centre des Maladies du Sein Deschênes-Fabia, Hôpital du Saint-Sacrement, CHA Universitaire de Québec, 1050 chemin Sainte-Foy, Québec City, QC, Canada G1S 4L8.

PMID: 22611503 PMCID: PMC3350177 DOI: 10.1155/2011/517047

Abstract

Background. Primary breast angiosarcoma is a rare entity. Case. Initial diagnosis was a benign hemangioma at core biopsy. Wide local excision was performed, with positive margins. Pathology after surgery reported a moderately differentiated angiosarcoma. Tumor was finally treated using mastectomy and radiations. She developed a second angiosarcoma in contralateral breast, with an initial diagnosis on core biopsy of an atypical vascular lesion and was again treated using mastectomy and radiations. She developed bones and lung metastases. Conclusion. Primary breast angiosarcoma is a rare entity often difficult to diagnose on core biopsy, and a benign differential diagnosis is frequent. A highly vascular breast mass should always be considered malignant until proven otherwise. Surgical treatment seems to be the best course of action. There is a lack of data proving efficacy of adjuvant chemotherapy and radiation therapy.

References

  1. Arch Surg. 1995 Feb;130(2):221-3 - PubMed
  2. J Surg Oncol. 2004 Sep 1;87(3):121-5 - PubMed
  3. Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):383-90 - PubMed
  4. J Am Acad Dermatol. 2010 Oct;63(4):e83-4 - PubMed
  5. Cancer. 1980 Jul 15;46(2):368-71 - PubMed
  6. Curr Surg. 2002 Sep-Oct;59(5):490-4 - PubMed
  7. Cancer. 2007 Jul 1;110(1):173-8 - PubMed
  8. Arch Surg. 1986 Jun;121(6):669-72 - PubMed
  9. Eur J Surg Oncol. 1993 Feb;19(1):61-9 - PubMed
  10. Breast Cancer. 2006;13(4):369-73 - PubMed
  11. J Surg Oncol. 2010 Apr 1;101(5):401-7 - PubMed
  12. Cancer Invest. 1998;16(7):442-6 - PubMed
  13. Cancer. 2005 Dec 15;104(12):2682-8 - PubMed
  14. Cancer. 1962 Mar-Apr;15:418-24 - PubMed
  15. J Clin Oncol. 2003 Jul 1;21(13):2583-8 - PubMed
  16. J Clin Oncol. 2008 Nov 10;26(32):5269-74 - PubMed
  17. Ann Diagn Pathol. 2009 Jun;13(3):147-50 - PubMed
  18. Clin Med Insights Oncol. 2010 Oct 12;4:107-10 - PubMed
  19. Br J Dermatol. 2010 Jul;163(1):225-7 - PubMed
  20. Clin Nucl Med. 2009 Jul;34(7):443-5 - PubMed
  21. Eur J Cancer Prev. 2009 Aug;18(4):280-4 - PubMed
  22. Lancet Oncol. 2006 Jun;7(6):521-3 - PubMed
  23. Cancer. 1999 Nov 15;86(10):2034-7 - PubMed
  24. Curr Opin Oncol. 2010 Jul;22(4):351-5 - PubMed
  25. Cancer. 1993 Jan 1;71(1):138-41 - PubMed
  26. Target Oncol. 2011 Mar;6(1):29-39 - PubMed
  27. Am J Surg. 2008 Oct;196(4):559-61 - PubMed
  28. Tumori. 2009 Nov-Dec;95(6):828-31 - PubMed
  29. J Thorac Oncol. 2011 May;6(5):970-1 - PubMed
  30. Jpn J Clin Oncol. 1997 Apr;27(2):91-4 - PubMed
  31. Ann Surg. 1985 Apr;201(4):527-32 - PubMed
  32. Breast J. 2005 Nov-Dec;11(6):517-8 - PubMed
  33. Br J Cancer. 2004 Jul 19;91(2):237-41 - PubMed
  34. Radiology. 1992 Jun;183(3):649-54 - PubMed
  35. AJR Am J Roentgenol. 2008 Feb;190(2):533-8 - PubMed
  36. Br J Plast Surg. 2003 Mar;56(2):129-34 - PubMed
  37. Surgery. 1994 Sep;116(3):505-9 - PubMed
  38. Clin Ther. 2006 Nov;28(11):1779-802 - PubMed

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