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Kaul G, Thippeswamy H. Role of heat shock proteins in diseases and their therapeutic potential. Indian J Microbiol. 2011;51(2):124-31doi: 10.1007/s12088-011-0147-9.
Kaul, G., & Thippeswamy, H. (2011). Role of heat shock proteins in diseases and their therapeutic potential. Indian journal of microbiology, 51(2), 124-31. https://doi.org/10.1007/s12088-011-0147-9
Kaul, Gautam, and Thippeswamy, Hitesh. "Role of heat shock proteins in diseases and their therapeutic potential." Indian journal of microbiology vol. 51,2 (2011): 124-31. doi: https://doi.org/10.1007/s12088-011-0147-9
Kaul G, Thippeswamy H. Role of heat shock proteins in diseases and their therapeutic potential. Indian J Microbiol. 2011 Jun;51(2):124-31. doi: 10.1007/s12088-011-0147-9. Epub 2011 Feb 09. PMID: 22654152; PMCID: PMC3209880.
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Indian J Microbiol. 2011 Jun;51(2):124-31. doi: 10.1007/s12088-011-0147-9. Epub 2011 Feb 09.

Role of heat shock proteins in diseases and their therapeutic potential.

Indian journal of microbiology

Gautam Kaul, Hitesh Thippeswamy

Affiliations

  1. Biochemistry Department, National Dairy Research Institute, Karnal, Haryana India.

PMID: 22654152 PMCID: PMC3209880 DOI: 10.1007/s12088-011-0147-9

Abstract

Heat shock proteins are ubiquitously expressed intracellular proteins and act as molecular chaperones in processes like protein folding and protein trafficking between different intracellular compartments. They are induced during stress conditions like oxidative stress, nutritional deficiencies and radiation. They are released into extracellular compartment during necrosis. However, recent research findings highlights that, they are not solely present in cytoplasm, but also released into extracellular compartment during normal conditions and even in the absence of necrosis. When present in extracellular compartment, they have been shown to perform various functions like antigen presentation, intercellular signaling and induction of pro-inflammatory cytokines. Heat shock proteins represents as dominant microbial antigens during infection. The phylogenetic similarity between prokaryotic and eukaryotic heat shock proteins has led to proposition that, microbial heat shock proteins can induce self reactivity to host heat shock proteins and result in autoimmune diseases. The self-reactivity of heat shock proteins protects host against disease by controlling induction and release of pro-inflammatory cytokines. However, antibodies to self heat shock proteins haven been implicated in pathogenesis of autoimmune diseases like arthritis and atherosclerosis. Some heat shock proteins are potent inducers of innate and adaptive immunity. They activate dendritic cells and natural killer cells through toll-like receptors, CD14 and CD91. They play an important role in MHC-antigen processing and presentation. These immune effector functions of heat shock proteins are being exploited them as therapeutic agents as well as therapeutic targets for various infectious diseases and cancers.

Keywords: Autoimmune diseases; Chaperone; Heat shock proteins; Infectious diseases

References

  1. J Exp Med. 1995 Mar 1;181(3):943-52 - PubMed
  2. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1475-8 - PubMed
  3. Science. 2002 Mar 8;295(5561):1852-8 - PubMed
  4. J Exp Med. 1989 Aug 1;170(2):449-66 - PubMed
  5. Trends Biochem Sci. 1991 Apr;16(4):135-40 - PubMed
  6. J Immunol. 1999 Mar 15;162(6):3212-9 - PubMed
  7. Infect Immun. 1997 Feb;65(2):699-707 - PubMed
  8. Clin Exp Immunol. 1992 Jan;87(1):99-104 - PubMed
  9. J Biol Chem. 2001 Aug 17;276(33):31332-9 - PubMed
  10. Immunol Lett. 2004 Jun 15;94(1-2):1-10 - PubMed
  11. J Exp Med. 1993 Oct 1;178(4):1391-6 - PubMed
  12. Drug Discov Today. 2006 Jun;11(11-12):534-40 - PubMed
  13. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6499-503 - PubMed
  14. EMBO J. 2000 Nov 15;19(22):5971-9 - PubMed
  15. Curr Top Microbiol Immunol. 1991;167:145-60 - PubMed
  16. Immunol Lett. 1997 Jun 1;57(1-3):69-74 - PubMed
  17. Infect Immun. 1995 Jul;63(7):2587-95 - PubMed
  18. J Immunol. 1993 Mar 1;150(5):2025-32 - PubMed
  19. Biochem Biophys Res Commun. 2004 Sep 24;322(3):899-904 - PubMed
  20. Infect Immun. 1988 Feb;56(2):446-51 - PubMed
  21. J Exp Med. 2000 Jun 5;191(11):1965-74 - PubMed
  22. Sci Am. 1993 May;268(5):56-64 - PubMed
  23. Annu Rev Genet. 1988;22:631-77 - PubMed
  24. J Exp Med. 1992 Jan 1;175(1):49-56 - PubMed
  25. EMBO J. 1994 Feb 15;13(4):934-44 - PubMed
  26. Expert Opin Emerg Drugs. 2005 Feb;10(1):137-49 - PubMed
  27. Scand J Immunol. 1994 Jun;39(6):613-7 - PubMed
  28. Am J Pathol. 1990 Nov;137(5):1013-7 - PubMed
  29. Nat Immunol. 2000 Aug;1(2):151-5 - PubMed
  30. J Leukoc Biol. 2004 Sep;76(3):514-9 - PubMed
  31. Crit Rev Eukaryot Gene Expr. 1994;4(4):357-401 - PubMed
  32. Science. 1994 Jan 21;263(5145):384-7 - PubMed
  33. Mol Microbiol. 1991 Feb;5(2):401-7 - PubMed
  34. J Exp Med. 1992 Jun 1;175(6):1805-10 - PubMed
  35. EMBO J. 2003 Nov 17;22(22):6127-36 - PubMed
  36. Am J Pathol. 1993 Jun;142(6):1927-37 - PubMed
  37. J Biol Chem. 2005 Jun 3;280(22):20961-7 - PubMed
  38. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5189-93 - PubMed
  39. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3077-81 - PubMed
  40. Immunol Today. 1992 Mar;13(3):86-9 - PubMed
  41. J Immunol. 1994 Jun 1;152(11):5398-403 - PubMed
  42. J Clin Invest. 1999 Feb;103(4):571-7 - PubMed
  43. J Cell Biol. 2002 Sep 30;158(7):1277-85 - PubMed
  44. J Exp Med. 1989 Dec 1;170(6):1799-809 - PubMed
  45. EMBO J. 1994 Feb 1;13(3):675-82 - PubMed
  46. Springer Semin Immunopathol. 1991;13(1):25-36 - PubMed
  47. Curr Top Microbiol Immunol. 1990;155:125-41 - PubMed
  48. Genes Dev. 1996 Nov 1;10(21):2782-93 - PubMed
  49. Nature. 1994 Aug 4;370(6488):373-5 - PubMed
  50. Science. 1989 Jul 28;245(4916):385-90 - PubMed
  51. Trends Biochem Sci. 1994 Jan;19(1):20-5 - PubMed
  52. J Exp Med. 1994 Jul 1;180(1):407-12 - PubMed
  53. J Immunol. 2000 Jan 1;164(1):13-7 - PubMed
  54. Semin Immunol. 1991 Jan;3(1):25-33 - PubMed
  55. Int Immunol. 1989;1(2):191-6 - PubMed
  56. Immunology. 1994 Jun;82(2):244-8 - PubMed
  57. Infect Immun. 1996 Aug;64(8):2955-61 - PubMed
  58. Mol Biochem Parasitol. 1989 Mar 15;33(3):229-35 - PubMed
  59. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4267-70 - PubMed
  60. Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):130-1 - PubMed
  61. J Cell Biochem. 1997 Oct 1;67(1):43-54 - PubMed
  62. Science. 1990 May 11;248(4956):730-2 - PubMed
  63. Curr Opin Immunol. 1995 Feb;7(1):77-84 - PubMed
  64. Experientia. 1994 Nov 30;50(11-12):1031-8 - PubMed
  65. Immunol Today. 1995 May;16(5):243-50 - PubMed
  66. Atherosclerosis. 1999 Jul;145(1):33-43 - PubMed
  67. Physiol Rev. 1999 Apr;79(2):425-49 - PubMed
  68. J Biol Chem. 2002 Apr 26;277(17):15028-34 - PubMed
  69. Infect Immun. 1994 Dec;62(12):5689-93 - PubMed
  70. Br J Rheumatol. 1990 Dec;29(6):426-9 - PubMed
  71. Nat Rev Immunol. 2002 Mar;2(3):185-94 - PubMed
  72. Infect Immun. 1988 Aug;56(8):2047-53 - PubMed

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