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Faraldi F, Papa V, Santoro D, et al. A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions. Clin Ophthalmol. 2012;6:727-31doi: 10.2147/OPTH.S31776.
Faraldi, F., Papa, V., Santoro, D., Rasà, D., Mazza, A. L., Rabbione, M. M., & Russo, S. (2012). A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions. Clinical ophthalmology (Auckland, N.Z.), 6727-31. https://doi.org/10.2147/OPTH.S31776
Faraldi, Francesco, et al. "A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions." Clinical ophthalmology (Auckland, N.Z.) vol. 6 (2012): 727-31. doi: https://doi.org/10.2147/OPTH.S31776
Faraldi F, Papa V, Santoro D, Rasà D, Mazza AL, Rabbione MM, Russo S. A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions. Clin Ophthalmol. 2012;6:727-31. doi: 10.2147/OPTH.S31776. Epub 2012 May 09. PMID: 22654499; PMCID: PMC3363309.
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Clin Ophthalmol. 2012;6:727-31. doi: 10.2147/OPTH.S31776. Epub 2012 May 09.

A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions.

Clinical ophthalmology (Auckland, N.Z.)

Francesco Faraldi, Vincenzo Papa, Debora Santoro, Daria Rasà, Annamaria L Mazza, Maria M Rabbione, Simona Russo

Affiliations

  1. Department of Ophthalmology III, Presidio Ospedaliero Oftalmico, Torino, Italy.

PMID: 22654499 PMCID: PMC3363309 DOI: 10.2147/OPTH.S31776

Abstract

PURPOSE: The aim of this study was to investigate the effects of an ophthalmic gel containing sodium hyaluronate and xanthan gum in addition to the antibiotic netilmicin in the management of traumatic corneal abrasions.

PATIENTS AND METHODS: PATIENTS WITH TRAUMATIC CORNEAL ABRASIONS WERE RANDOMLY TREATED AS FOLLOWS: Group A (n = 20) with an occlusive patching for 12 hours plus one drop of an eye gel containing 0.15% sodium hyaluronate, 1% xanthan gum and 0.3% netilmicin qid for 5 days; and Group B (n = 20) with an occlusive patching for 2-3 days plus one application of 0.3% netilmicin ophthalmic ointment qid for 5 days. All patients were evaluated after the third and seventh day by slit-lamp examination, fluorescein staining, and corneal defect photograph in order to assess corneal re-epithelialization. Conjunctival hyperaemia, lid oedema, subjective symptoms of discomfort, and conjunctival swabs were also evaluated.

RESULTS: No statistically significant difference was observed between the groups in terms of the extent of corneal healing after 3 days of treatment. Both treatments were also highly effective in decreasing the erosion score and the conjunctival hyperemia (P < 0.0001, P < 0.005, respectively) without any significant difference between the two types of treatment. Subjective symptoms of discomfort and conjunctival swabs were also evaluated.

CONCLUSION: In the management of traumatic corneal abrasions, the administration of an eye gel containing sodium hyaluronate and xanthan gum is able to reduce the length of occlusive patching. In addition, the presence of netilmicin guarantees good antibiotic prophylaxis during the wound repair process.

Keywords: corneal abrasion; netilmicin; patching; wound healing; xanthan gum

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