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Martin SB, Dowling AL, Head E. Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Curr Neuropharmacol. 2011;9(4):651-61doi: 10.2174/157015911798376217.
Martin, S. B., Dowling, A. L., & Head, E. (2011). Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Current neuropharmacology, 9(4), 651-61. https://doi.org/10.2174/157015911798376217
Martin, Sarah B, et al. "Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model." Current neuropharmacology vol. 9,4 (2011): 651-61. doi: https://doi.org/10.2174/157015911798376217
Martin SB, Dowling AL, Head E. Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Curr Neuropharmacol. 2011 Dec;9(4):651-61. doi: 10.2174/157015911798376217. PMID: 22654723; PMCID: PMC3263459.
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Curr Neuropharmacol. 2011 Dec;9(4):651-61. doi: 10.2174/157015911798376217.

Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model.

Current neuropharmacology

Sarah B Martin, Amy L S Dowling, Elizabeth Head

Affiliations

  1. Sanders Brown Center on Aging, University of Kentucky, Lexington KY, USA.

PMID: 22654723 PMCID: PMC3263459 DOI: 10.2174/157015911798376217

Abstract

Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimer's Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregation and increased clearance of Aβ. The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting Aβ.

Keywords: A-beta vaccination.; Alzheimer's disease; BACE-1 inhibitors; canine; metal-chelators; statins

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