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Hernandez M, Recio G, Martin-Palma RJ, et al. Surface enhanced fluorescence of anti-tumoral drug emodin adsorbed on silver nanoparticles and loaded on porous silicon. Nanoscale Res Lett. 2012;7(1):364doi: 10.1186/1556-276X-7-364.
Hernandez, M., Recio, G., Martin-Palma, R. J., Garcia-Ramos, J. V., Domingo, C., & Sevilla, P. (2012). Surface enhanced fluorescence of anti-tumoral drug emodin adsorbed on silver nanoparticles and loaded on porous silicon. Nanoscale research letters, 7(1), 364. https://doi.org/10.1186/1556-276X-7-364
Hernandez, Margarita, et al. "Surface enhanced fluorescence of anti-tumoral drug emodin adsorbed on silver nanoparticles and loaded on porous silicon." Nanoscale research letters vol. 7,1 (2012): 364. doi: https://doi.org/10.1186/1556-276X-7-364
Hernandez M, Recio G, Martin-Palma RJ, Garcia-Ramos JV, Domingo C, Sevilla P. Surface enhanced fluorescence of anti-tumoral drug emodin adsorbed on silver nanoparticles and loaded on porous silicon. Nanoscale Res Lett. 2012 Jul 02;7(1):364. doi: 10.1186/1556-276X-7-364. PMID: 22748115; PMCID: PMC3447710.
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Nanoscale Res Lett. 2012 Jul 02;7(1):364. doi: 10.1186/1556-276X-7-364.

Surface enhanced fluorescence of anti-tumoral drug emodin adsorbed on silver nanoparticles and loaded on porous silicon.

Nanoscale research letters

Margarita Hernandez, Gonzalo Recio, Raul J Martin-Palma, Jose V Garcia-Ramos, Concepcion Domingo, Paz Sevilla

Affiliations

  1. Instituto de Estructura de la Materia, IEM-CSIC, Serrano 121, Madrid, 28006, Spain. [email protected].

PMID: 22748115 PMCID: PMC3447710 DOI: 10.1186/1556-276X-7-364

Abstract

Fluorescence spectra of anti-tumoral drug emodin loaded on nanostructured porous silicon have been recorded. The use of colloidal nanoparticles allowed embedding of the drug without previous porous silicon functionalization and leads to the observation of an enhancement of fluorescence of the drug. Mean pore size of porous silicon matrices was 60 nm, while silver nanoparticles mean diameter was 50 nm. Atmospheric and vacuum conditions at room temperature were used to infiltrate emodin-silver nanoparticles complexes into porous silicon matrices. The drug was loaded after adsorption on metal surface, alone, and bound to bovine serum albumin. Methanol and water were used as solvents. Spectra with 1 μm spatial resolution of cross-section of porous silicon layers were recorded to observe the penetration of the drug. A maximum fluorescence enhancement factor of 24 was obtained when protein was loaded bound to albumin, and atmospheric conditions of inclusion were used. A better penetration was obtained using methanol as solvent when comparing with water. Complexes of emodin remain loaded for 30 days after preparation without an apparent degradation of the drug, although a decrease in the enhancement factor is observed. The study reported here constitutes the basis for designing a new drug delivery system with future applications in medicine and pharmacy.

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