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Gri G, Frossi B, D'Inca F, et al. Mast cell: an emerging partner in immune interaction. Front Immunol. 2012;3:120doi: 10.3389/fimmu.2012.00120.
Gri, G., Frossi, B., D'Inca, F., Danelli, L., Betto, E., Mion, F., Sibilano, R., & Pucillo, C. (2012). Mast cell: an emerging partner in immune interaction. Frontiers in immunology, 3120. https://doi.org/10.3389/fimmu.2012.00120
Gri, Giorgia, et al. "Mast cell: an emerging partner in immune interaction." Frontiers in immunology vol. 3 (2012): 120. doi: https://doi.org/10.3389/fimmu.2012.00120
Gri G, Frossi B, D'Inca F, Danelli L, Betto E, Mion F, Sibilano R, Pucillo C. Mast cell: an emerging partner in immune interaction. Front Immunol. 2012 May 25;3:120. doi: 10.3389/fimmu.2012.00120. eCollection 2012. PMID: 22654879; PMCID: PMC3360165.
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Front Immunol. 2012 May 25;3:120. doi: 10.3389/fimmu.2012.00120. eCollection 2012.

Mast cell: an emerging partner in immune interaction.

Frontiers in immunology

Giorgia Gri, Barbara Frossi, Federica D'Inca, Luca Danelli, Elena Betto, Francesca Mion, Riccardo Sibilano, Carlo Pucillo

Affiliations

  1. Immunology Laboratory, Department of Medical and Biological Science, University of Udine Udine, Italy.

PMID: 22654879 PMCID: PMC3360165 DOI: 10.3389/fimmu.2012.00120

Abstract

Mast cells (MCs) are currently recognized as effector cells in many settings of the immune response, including host defense, immune regulation, allergy, chronic inflammation, and autoimmune diseases. MC pleiotropic functions reflect their ability to secrete a wide spectrum of preformed or newly synthesized biologically active products with pro-inflammatory, anti-inflammatory and/or immunosuppressive properties, in response to multiple signals. Moreover, the modulation of MC effector phenotypes relies on the interaction of a wide variety of membrane molecules involved in cell-cell or cell-extracellular-matrix interaction. The delivery of co-stimulatory signals allows MC to specifically communicate with immune cells belonging to both innate and acquired immunity, as well as with non-immune tissue-specific cell types. This article reviews and discusses the evidence that MC membrane-expressed molecules play a central role in regulating MC priming and activation and in the modulation of innate and adaptive immune response not only against host injury, but also in peripheral tolerance and tumor-surveillance or -escape. The complex expression of MC surface molecules may be regarded as a measure of connectivity, with altered patterns of cell-cell interaction representing functionally distinct MC states. We will focalize our attention on roles and functions of recently discovered molecules involved in the cross-talk of MCs with other immune partners.

Keywords: adaptive immunity; cell–cell interaction; innate immunity; mast cell

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