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Melkikh AV, Sutormina MI. Algorithms for optimization of the transport system in living and artificial cells. Syst Synth Biol. 2011;5(1):87-96doi: 10.1007/s11693-011-9083-6.
Melkikh, A. V., & Sutormina, M. I. (2011). Algorithms for optimization of the transport system in living and artificial cells. Systems and synthetic biology, 5(1), 87-96. https://doi.org/10.1007/s11693-011-9083-6
Melkikh, A V, and Sutormina, M I. "Algorithms for optimization of the transport system in living and artificial cells." Systems and synthetic biology vol. 5,1 (2011): 87-96. doi: https://doi.org/10.1007/s11693-011-9083-6
Melkikh AV, Sutormina MI. Algorithms for optimization of the transport system in living and artificial cells. Syst Synth Biol. 2011 Jun;5(1):87-96. doi: 10.1007/s11693-011-9083-6. Epub 2011 Jun 17. PMID: 22654996; PMCID: PMC3159698.
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Syst Synth Biol. 2011 Jun;5(1):87-96. doi: 10.1007/s11693-011-9083-6. Epub 2011 Jun 17.

Algorithms for optimization of the transport system in living and artificial cells.

Systems and synthetic biology

A V Melkikh, M I Sutormina

Affiliations

  1. Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia.

PMID: 22654996 PMCID: PMC3159698 DOI: 10.1007/s11693-011-9083-6

Abstract

An optimization of the transport system in a cell has been considered from the viewpoint of the operations research. Algorithms for an optimization of the transport system of a cell in terms of both the efficiency and a weak sensitivity of a cell to environmental changes have been proposed. The switching of various systems of transport is considered as the mechanism of weak sensitivity of a cell to changes in environment. The use of the algorithms for an optimization of a cardiac cell has been considered by way of example. We received theoretically for a cell of a cardiac muscle that at the increase of potassium concentration in the environment switching of transport systems for this ion takes place. This conclusion qualitatively coincides with experiments. The problem of synthesizing an optimal system in an artificial cell has been stated.

Keywords: Efficiency; Game theory; Robustness; Synthetic biology; Systems biology; Transport of ions

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