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Khamesipour A, Abbasi A, Firooz A, et al. Treatment of cutaneous lesion of 20 years' duration caused by leishmanization. Indian J Dermatol. 2012;57(2):123-5doi: 10.4103/0019-5154.94280.
Khamesipour, A., Abbasi, A., Firooz, A., Mohammadi, A. M., Eskandari, S. E., & Jaafari, M. R. (2012). Treatment of cutaneous lesion of 20 years' duration caused by leishmanization. Indian journal of dermatology, 57(2), 123-5. https://doi.org/10.4103/0019-5154.94280
Khamesipour, Ali, et al. "Treatment of cutaneous lesion of 20 years' duration caused by leishmanization." Indian journal of dermatology vol. 57,2 (2012): 123-5. doi: https://doi.org/10.4103/0019-5154.94280
Khamesipour A, Abbasi A, Firooz A, Mohammadi AM, Eskandari SE, Jaafari MR. Treatment of cutaneous lesion of 20 years' duration caused by leishmanization. Indian J Dermatol. 2012 Mar;57(2):123-5. doi: 10.4103/0019-5154.94280. PMID: 22615509; PMCID: PMC3352634.
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Indian J Dermatol. 2012 Mar;57(2):123-5. doi: 10.4103/0019-5154.94280.

Treatment of cutaneous lesion of 20 years' duration caused by leishmanization.

Indian journal of dermatology

Ali Khamesipour, Azam Abbasi, Alireza Firooz, Akram Mir Amin Mohammadi, Seyed Ebrahim Eskandari, Mahmoud R Jaafari

Affiliations

  1. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 22615509 PMCID: PMC3352634 DOI: 10.4103/0019-5154.94280

Abstract

The inoculation of live Leishmania (L.) major to produce a single lesion is called leishmanization (LZ). LZ lesion upon cure prevents further natural infection which might be multiple lesions on unwanted sites such as face. Cutaneous leishmaniasis (CL) usually leads to a self healing lesion; though rarely the lesion persists and becomes refractory to all types of remedies. Here, we present a 41-year-old patient with a 20-year history of cutaneous lesion caused by leishmanization. The causative agent is identified as L. major. The patient did not respond to treatment with meglumine antimoniate, 20 mg/kg/day Sb(+5) for three weeks and allopurinol 10 mg/kg for four weeks. After two months, the same treatment was repeated. In addition, a topical liposomal preparation containing 10% paromomycin sulfate was administered twice a day for four weeks. The lesion showed marked improvement during the treatment and was eventually completely healed.

Keywords: L. major lesion; Leishmanization; non-healing; paromomycin; treatment of cutaneous leishmaniasis

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