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Anel A, Aguiló JI, Catalán E, et al. Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity. Front Immunol. 2012;3:187doi: 10.3389/fimmu.2012.00187.
Anel, A., Aguiló, J. I., Catalán, E., Garaude, J., Rathore, M. G., Pardo, J., & Villalba, M. (2012). Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity. Frontiers in immunology, 3187. https://doi.org/10.3389/fimmu.2012.00187
Anel, Alberto, et al. "Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity." Frontiers in immunology vol. 3 (2012): 187. doi: https://doi.org/10.3389/fimmu.2012.00187
Anel A, Aguiló JI, Catalán E, Garaude J, Rathore MG, Pardo J, Villalba M. Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity. Front Immunol. 2012 Jul 05;3:187. doi: 10.3389/fimmu.2012.00187. eCollection 2012. PMID: 22783260; PMCID: PMC3389606.
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Front Immunol. 2012 Jul 05;3:187. doi: 10.3389/fimmu.2012.00187. eCollection 2012.

Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity.

Frontiers in immunology

Alberto Anel, Juan I Aguiló, Elena Catalán, Johan Garaude, Moeez G Rathore, Julián Pardo, Martín Villalba

Affiliations

  1. Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza Zaragoza, Spain.

PMID: 22783260 PMCID: PMC3389606 DOI: 10.3389/fimmu.2012.00187

Abstract

The protein kinase C-θ (PKCθ), which is essential for T cell function and survival, is also required for efficient anti-tumor immune surveillance. Natural killer (NK) cells, which express PKCθ, play a prominent role in this process, mainly by elimination of tumor cells with reduced or absent major histocompatibility complex class-I (MHC-I) expression. This justifies the increased interest of the use of activated NK cells in anti-tumor immunotherapy in the clinic. The in vivo development of MHC-I-deficient tumors is much favored in PKCθ(-/-) mice compared with wild-type mice. Recent data offer some clues on the mechanism that could explain the important role of PKCθ in NK cell-mediated anti-tumor immune surveillance: some studies show that PKCθ is implicated in signal transduction and anti-tumoral activity of NK cells elicited by interleukin (IL)-12 or IL-15, while others show that it is implicated in NK cell functional activation mediated by certain killer-activating receptors. Alternatively, the possibility that PKCθ is involved in NK cell degranulation is discussed, since recent data indicate that it is implicated in microtubule-organizing center polarization to the immune synapse in CD4(+) T cells. The implication of PKC isoforms in degranulation has been more extensively studied in cytotoxic T lymphocyte, and these studies will be also summarized.

Keywords: CTL; NK cells; PKC-θ; anti-tumor immunity

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